background: our knowledge regarding the epidemiology of pancreatobiliary cancers in iran is limited. this study presents the first population-based report on pancreatobiliary cancers performed in five provinces of iran. materials andmethods: data used in this study were retrieved from population-based cancer registries in five provinces of iran (gilan, mazandaran, golestan, ardabil and kerman) ...

pancreatic cancer (pc) is a progressive, fatal disease with a high degree of malignancy. more than 40000 peoplediefrom this cancer annually in the united states. as a multifactorial condition, pc has a complex nature, and there are several genes and signalingpathwaysimplicated in pc pathogenesis and progression. there are diffèrent mutations in master genesincludingtumorsuppressors and oncogene...

oxaliplatin, a third generation of platinum-based anti-neoplastic agent has been approved for colorectal cancer in both adjuvant and metastatic settings. in addition, oxaliplatin is also indicated for other gastrointestinal malignancies such as metastatic pancreatic cancer in combination with gemcitabine. its common toxicities include infusional hypersensitivity reaction (hsr), gi symptoms with...

introduction : severepain is a major problem in patients with unresectable pancreatic cancer. the goal of this study is to evaluate the effects of thoracoscopic splanchnicectomy (ts) on pain control in these patients suffering from unresectable pancreatic cancer. methods:between years 2000 to 2011, 20 patients suffering from unresectable pancreatic cancer underwent ts due to severe pain. they w...

the p53 protein function is essential for the maintenance of the nontumorigenic cell phenotype. pancreatic tumor cells show a very high frequency of p53 mutation. to determine if restoration of wild type p53 function can be used to eliminate the tumorigenic phenotype in these cells, pancreatic tumor cell lines, panc-1 and htb80, differing in p53 status were stably transfected with exogenous wil...

Background: Among all types of cancers, pancreatic cancer has poor prognosis with 5-year survival below 10%. In theory, alcohol intake may be a modifiable risk factor for pancreatic cancer due to its role in multiple carcinogenic and metabolic signaling pathways. In addition, alcohol consumption may lead to chronic pancreatitis which is underlying cause of pancreatic cancer. However, little is ...

the purpose of this study was to evaluate the therapeutic result of ct -guided celiac plexus block for managing intractable upper abdominal pain due to pancreatic carcinoma or chronic pancreatitis. we treated 22 cancer patients who were on regular narcotic medication. after an iv infusion of 10mllkg ringer's lactate solution, all patients were rolled onto prone position, and lidocaine was ...

background: more than 250,000 people die annually of pancreatic cancer, worldwide. the highest incidence and mortality rates of pancreatic cancer are reported in developed countries. in developing countries the rate have been stabilizing over the past two decades but in countries which rates have been low for decades is now increasing. recognizing pancreatic cancer's risk factors and its preven...

compared to western countries, pancreatic cancer has a relatively low incidence in iran. it is rarely diagnosed before the fifth decade in iran and most of the patients are older than 60 at the time of diagnosis like to the western countries, where pancreatic cancer is a disease of advanced age. the incidence of the disease in some young patients suggests a possible role of genetic defects, whi...