نتایج جستجو برای: Pancreatic β-cell

تعداد نتایج: 1877157  

M. Bello Ibrahim, Mohammed Abdullahi,

Objective: Pancreatic b-cell dysfunction is described to be present at the diagnosis of type 2 diabetes mellitus (T2DM) and progressively deteriorated with disease duration. However, its progression is variable and potentially influenced by several factors. The Magnesium (Mg) deficiency mediates insulin resistance but reports regarding its role in pancreatic β-cell dysfunction are scarce and co...

ژورنال: دانشور پزشکی 2015
اسماعیلی, فریبا, خرازیان, نواز, منصورزاده, سمیه, هوشمند, فریبا,

Background and Objective: β cell replacement therapy by pancreatic islet transplantation has become a promising treatment for type 1 diabetes. Medicago sativa L (Lucerne) from leguminosae family is known to exhibit hypoglycaemic activity both in animal and human studies. Most of these studies were concentrated on the effects of plant extracts on fasting glucose levels. Until now no researches h...

Maryam Chinisaz, Robab Sheikhpour, Sepideh Jabbari,

Apoptosis is a complex network of biochemical and molecular pathway with fine regulatory mechanisms that control the death event during several pathological situations in multi cellular organisms. It is the part of normal development that occurs in a variety of diseases and is known as aberrant apoptosis. Pancreatic β cell apoptosis is also a pathological feature which is common in both type 1 ...

Journal: :iranian journal of diabetes and obesity 0
robab sheikhpour department of nursing, yazd medical science branch, islamic azad university, yazd, iran maryam chinisaz department of biology, science and research branch, islamic azad university, tehran, iran sepideh jabbari department of biology, science and research branch, islamic azad university, tehran, iran

apoptosis is a complex network of biochemical and molecular pathway with fine regulatory mechanisms that control the death event during several pathological situations in multi cellular organisms. it is the part of normal development that occurs in a variety of diseases and is known as aberrant apoptosis. pancreatic β cell apoptosis is also a pathological feature which is common in both type 1 ...

Journal: :The Kobe journal of medical sciences 2013
Yuki Shibutani Shun-Ichiro Asahara Kyoko Teruyama Hiroyuki Inoue Tomokazu Matsuda Susumu Seino Yoshiaki Kido

Insulin secretion from pancreatic β cells has an important role in the onset of type 2 diabetes. Insulin secretion from pancreatic β cells is regulated by pancreatic β cell mass and their insulin secretory function. By using pancreatic β cell-specific Rac1-knockout mice, we recently showed that Rac1 deletion, even with no reduction in pancreatic β cell mass, inhibits F-actin depolymerization, w...

Journal: :Journal of diabetes research 2021

Pancreatic β-cell neogenesis in vivo holds great promise for cell replacement therapy diabetic patients, and discovering the relevant clinical therapeutic strategies would push it forward to application. Liraglutide, a widely used antidiabetic glucagon-like peptide-1 (GLP-1) analog, has displayed diverse β-cell-protective effects type 2 animals. Glucagon receptor (GCGR) monoclonal antibody (mAb...

2010
Chunjiong Wang Youfei Guan Jichun Yang

The dysfunction of pancreatic β-cell and the reduction in β-cell mass are the decisive events in the progression of type 2 diabetes. There is increasing evidence that cytokines play important roles in the procedure of β-cell failure. Cytokines, such as IL-1β, IFN-γ, TNF-α, leptin, resistin, adiponectin, and visfatin, have been shown to diversely regulate pancreatic β-cell function. Recently, is...

Journal: :Diabetes 2014
Yoko Yagishita Toshiaki Fukutomi Akira Sugawara Hiroshi Kawamura Tetsu Takahashi Jingbo Pi Akira Uruno Masayuki Yamamoto

Transcription factor Nrf2 (NF-E2-related factor 2) regulates wide-ranging cytoprotective genes in response to environmental stress. Keap1 (Kelch-like ECH-associated protein 1) is an adaptor protein for Cullin3-based ubiquitin E3 ligase and negatively regulates Nrf2. The Keap1-Nrf2 system plays important roles in the oxidative stress response and metabolism. However, the roles Nrf2 plays in prev...

Journal: :medical journal of islamic republic of iran 0
h f orootan from the department of gastroenterology, tehran university of medical sciences, tehran f mansour ghanaie the deparfment of gastroenterology, gastrointestinal & liver disease research center (gldrc), guilan university of medical sciences, rasht, i.r. iran h ghofrani from the department of gastroenterology, tehran university of medical sciences, tehran

primary pancreatic lymphoma is a rare extranodal manifestation of any histopathologic subtype of b cell non-hodgkin's lymphoma that predominantly involves the pancreas. it comprises less than 0.2% of pancreatic malignancies and less than 0.7% of non-hodgkin's lymphomas. this lymphoma is almost never suspected clinically. it is usually diagnosed by surgical exploration for suspected ad...

Background and Objective: Oxidative stress induced by proinflammatory cytokines such as IL-1β plays a major role in β-cell destruction in diabetes type 1. Salvianolic acid B (Sal B) is a polyphenolic compound with antioxidant and protective effects. Thus, objective of this study was to assess the protection exerted by Sal B on isolated rat islets exposed to IL-1β and to investigate an underlyin...

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