background: co-supplementation of unsaturated fatty acids (fas) with saturated fas may decrease the adverse effects of saturated fa-induced lipotoxicity. the objective of the present study was to evaluate the effect of palmitoleic acid (unsaturated fatty acid) on palmitic acid (saturated fatty acid) induced lipotoxicity criteria in the primary culture of adult rat cardiomyocytes. methods: cells...

Background: Co-supplementation of unsaturated fatty acids (FAs) with saturated FAs may decrease the adverse effects of saturated FA-induced lipotoxicity. The objective of the present study was to evaluate the effect of palmitoleic acid (unsaturated fatty acid) on palmitic acid (saturated fatty acid) induced lipotoxicity criteria in the primary culture of adult rat cardiomyocytes. Methods: Ce...

novel edible emulsified films were made using pistachio globulin protein (pgp) and palmitic fatty acid at concentrations of 2, 4, and 6 % w/w protein by tween-80 and homogenization technique. addition of palmitic acid to the pgp filmogenic solution resulted in great reduction of wvp in the emulsified films (37-40 %). concentration of palmitic acid did not create significant difference (p>0.05) ...

Background & Aims: Lipotoxicity is the process through which accumulation of lipid intermadiates leads to cellular dysfunction. The worldwide prevalence of cardiovascular diseases has been increased dramatically due to lipotoxicity. According to the peformed studies, saturated and unsaturated fatty acids differ significantly in their contributions to lipotoxicity. It has been r...

The effect of palmitic acid on basal and insulin-stimulated incorporation of glucose into rat adipocytes was studied. Palmitic acid (2.40 mM) stimulated basal as well as insulin-stimulated glucose incorporation in rat adipocytes three and twofold, respectively. Similar degrees of stimulation of basal glucose oxidation by palmitate were also observed. The ability of palmitic acid to stimulate gl...

Twenty-two genotypes of Brassica (B. rapa, B. juncea, and B. napus) were studied for correlation co-efficient between major fatty acids and path coefficient analysis to partition the cause and effect relationship into direct and indirect components. Correlation coefficient of major fatty acids revealed that significant and positive correlation was between palmitic and oleic acids, palmitic and ...

Background: Accumulation of palmitic acid in endothelial cells induces cellular dysfunction and death. Results: Palmitic acid triggers Ca 2+ -dependent autophagy, which results in programmed necrotic death (necroptosis) of endothelial cells. Conclusion: Autophagy promotes lipotoxic signaling of palmitic acid in endothelial cells leading to necroptosis. Significance: Showing a new molecular mech...

the aim of this study was to determine effects of different fatty acid profiles on rumen digestion coefficients, some of rumen metabolism parameters and rumen microbial populations. different oils were used as source of fatty acids such as, oleic, linoleic, linolenic, dha and epa. palmitic acid supplemented from a commercial product (bergafat t-300) containing high palmitic acid percentage. res...

To elucidate the mechanism for the previously reported increase in calcium sequestration by sarcoplasmic reticulum vesicles in the presence of palmitic acid, the ability of this fatty acid to bind calcium was investigated by dual wavelength spectrophotometry using the calcium indicator arsenazo III,, and by Millipore filtration using 45CaCl2. In the presence of 120 mM KCl, 1 mM MgCl2, 15 microM...