BACKGROUND Primary hypertrophic osteoarthropathy also known as pachydermoperiostosis is a rare genetic disorder that has often been confused with acromegaly because of similar clinical features. Vascular endothelial growth factors which have been implicated in the clinical features of pachydermoperiostosis, have also been shown to be present in chronic hepatitis and implicated in the malignant ...

INTRODUCTION Pachydermoperiostosis is a rare, hereditary disease commonly presenting with digital clubbing, pachydermia and periosteal hypertrophy. Therapeutic options for pachydermoperiostosis are few because of the unknown pathogenesis. Here, we report the complicated case of a patient with pachydermoperiostosis combined with spondyloarthritides, who was refractory to steroids and tumor necro...

Pachydermoperiostosis is a rare disease characterized by clubbing, periostosis, and soft tissue swelling, caused mutations in any of the genes involved prostaglandin metabolism (SCLO2A1 HPDG). Disease may also cause inflammatory arthritis included differential diagnosis juvenile chronic arthritis. A 17-year-old boy presented to our pediatric rheumatology outpatient clinic with complaints pain s...

INTRODUCTION Pachydermoperiostosis or primary hypertrophic osteoathropathy is a rare genetic disease with autosomal transmission. This disorder, which affects both bones and skin, is characterized by the association of dermatologic changes (pachydermia or thickening of the skin) and rheumatologic manifestations (periostosis and finger clubbing). Here, we report a new observation of pachydermope...

Pachydermoperiostosis or primary hypertrophic osteoarthropathy is an uncommon disease of acromegaloid facial feature, but characterized by unique phenotype (digital clubbing and pachydermia) and distinctive radiographic appearances like periostosis. We experienced a case with complete form of pachydermoperiostosis accompanied by heart failure. He presented with typical features consisting of cl...

Background: Pachydermoperiostosis is a rare inherited disorder occurring mainly in males and represents 5% of all cases of hypertrophic osteoarthropathy. It is characterized by the clinical triad of finger clubbing, periostitis and pachydermia. Unlike the secondary forms of hypertrophic osteoarthropathy, pachydermoperiostosis is not associated with cardiopulmonary diseases or malignancies. Case...

A unique case of pachydermoperiostosis, multiple epiphyseal dysplasia, and secondary osteoarthritis is described. An additional interesting feature was the presence of acroosteolysis of the distal phalanges of fingers and toes. Scintigraphic, thermographic, plethysmographic, and capillaroscopic studies suggested increased blood flow through clubbed fingers, raising the possibility that this may...

Pachydermoperiostosis is a rare hereditary disorder, which affects both bones and skin. It is characterized by a combination of dermatologic changes (pachydermia or thickening of the skin) and rheumatologic manifestations (periostosis and finger clubbing). Eyelid ptosis which is caused by thickened eyelids (blepharoptosis) is a less common symptom. We report the case of a patient with a complet...

We report on a 38-year-old male patient suffering from pachydermoperiostosis (Touraine-Solente-Golé Syndrome), who underwent a cosmetic operation without success.