We discovered a new spontaneous mutant allele of Npr2 named peewee (pwe) that exhibits severe disproportionate dwarfism and female infertility. The pwe phenotype is caused by a four base-pair deletion in exon 3 that generates a premature stop codon at codon 313 (L313X). The Npr2(pwe/pwe) mouse is a model for the human skeletal dysplasia acromesomelic dysplasia, Maroteaux type (AMDM). We conduct...

OBJECTIVES To ascertain the frequency of self-reported anger and depression in levetiracetam (LEV). DESIGN We compared patients with epilepsy (PWE) taking LEV with PWE taking other antiepileptic drugs (AEDs). SETTING All PWE and controls submitted information to the UK AED register. PARTICIPANTS We analysed the data of 418 PWE and 41 control participants. 158 participants took LEV in mono...

Since the beginning of propolis research, several groups have studied its antibacterial, antifungal, and antiviral properties. However, most of these studies have only employed propolis ethanolic extract (PEE) leading to little knowledge about the biological activities of propolis water extract (PWE). Based on this, in a previous study, we demonstrated the anti-inflammatory and immunomodulatory...

Neurocysticercosis (NCC) is a major cause of epilepsy in regions where pigs are free-ranging and hygiene is poor. Pork production is expected to increase in the next decade in sub-Saharan Africa, hence NCC will likely become more prevalent. In this study, people with epilepsy (PWE, n=212) were followed up 28.6 months after diagnosis of epilepsy. CT scans were performed, and serum and cerebrospi...

PURPOSE Pomegranate fruit, Punica granatum L. (Punicaceae), and its constituents have been shown to inhibit inflammation. In this study, we aimed to assess the effects of freeze-dried pomegranate (PWE) on PGE2 production in IL-1β-stimulated SK-N-SH cells. METHODS An enzyme immunoassay (EIA) was used to measure prostaglandin E2 (PGE2) production from supernatants of IL-1β-stimulated SK-N-SH ce...

BACKGROUND AND PURPOSE People with epilepsy (PWE) are more likely to experience suicidality, with suicidal ideation and attempts, than people without epilepsy (PWoE). The aims of the present study were to determine 1) the characteristics of suicidality in Korean PWE, 2) whether PWE with suicidality receive psychiatric intervention, and 3) the risk factors for suicidality. METHODS Patients who...

The investigation of teams and teamwork in cooperative (e.g., group brainstorming and team decisionmaking) and mixed-motive (e.g., negotiation) contexts has been carried out through a variety of lenses anddisciplines.One lens that has not beenused to rigorously theorize about andempirically investigate teams is that of ideologies. In this review, we juxtapose the study of a particular status-re...

PURPOSE Among the 50 million people with epilepsy (PWE) worldwide ∼15 to 60% likely also suffer from depression and/or anxiety and 80% reside in low-income regions where human and technological resources for care are extremely limited. METHODS In Zambia, we carried out a retrospective chart review of 200 randomly selected files of PWE using a structured abstraction form to systematically coll...

PURPOSE The study investigated how marital status relates to clinical aspects and quality of life (QOL) in patients with epilepsy (PWE). METHOD The clinical data and Quality of Life in Epilepsy Inventory (QOLIE-31) scores of 252 PWE were regressed against their marital status with a significance level of 5% (p < 0.05). RESULTS Logistic regression for single and married PWE revealed that sin...

The authors propose that, in the US, the Protestant work ethic (PWE) relates both to social tolerance and intolerance. PWE is proposed to have a surface meaning that relates to social tolerance, and also an associated meaning that relates to intolerance, which is acquired in part through social and cultural experience (e.g. PWE being used as a justifier of inequality). In correlational and expe...