نتایج جستجو برای: PTZ-inducedseizure threshold

تعداد نتایج: 123299  

Journal: :iranian journal of pharmaceutical sciences 0
mir hadi khayat nouri department of pharmacology, school of veterinary medicine, islamic azad university, tabriz, iran vahab babapour department of physiology, faculty of veterinary medicine, tehran university morteza samini department of pharmacology, faculty of medicine, tehran university of medical sciences/ tehran university, tehran, iran

gamma-aminobutyric acid (gaba) is an important inhibitory transmitter in central nervous system and is involved in pathophysiology of epilepsy. pentylenete-trazole (ptz), a convulsant agent, partly acts via anion channel of gabaa receptor. ivermectin, an antiparasitic agent and a gabaa agonist, has anticonvulsant effect in animal seizure models. cholestasis increases the threshold of ptz-induce...

Journal: :Acta biochimica et biophysica Sinica 2012
Ming Liu Zhejin Sheng Lei Cai Kai Zhao Yu Tian Jian Fei

Neuron restrictive silencer factor (NRSF), also known as repressor element-1 silencing transcription factor, has been reported to modulate neuronal excitability and acts as endogenous anticonvulsant in kainic acid-induced or kindling-evoked seizure activity. However, whether NRSF functions in pentylenetetrazol (PTZ)-induced seizure activity has never been studied. To investigate the role of end...

Journal: :Indian journal of experimental biology 2008
S K Kulkarni Kiran Kumar Akula Ashish Dhir

Withania somnifera (ashwagandha) is a widely used herb in the Ayurvedic system of medicine. The objective of the present study was to elucidate the effect of W. somnifera root extract (Ws) alone or in combination with exogenous gamma-amino butyric acid (GABA), a GABA receptor agonist or with diazepam, a GABA receptor modulator against pentylenetetrazol (PTZ, iv) seizure threshold in mice. Minim...

Journal: :Seizure 2011
Laleh Montaser-Kouhsari Borna Payandemehr Taha Gholipour Pouya Ziai Pooneh Nabavizadeh Abbas Ghasemi Arash Bahremand Mehdi Ghasemi Ahmad Reza Dehpour

There are several lines of evidence that opioidergic and nitrergic systems could modulate the seizure threshold. We previously have shown that sildenafil had proconvulsant effects in a model of clonic seizure induced by pentylenetetrazole (PTZ) or bicuculline. In the present study, we examined whether the opioid system participates in the action of sildenafil on the PTZ-induced clonic seizures ...

2014
Ana M. García-Cabrero Gentzane Sánchez-Elexpuru José M. Serratosa Marina P. Sánchez

Lafora disease is a rare form of inherited progressive myoclonus epilepsy caused by mutations in the EPM2A gene encoding laforin, or in the EPM2B gene, which encodes malin. It is characterized by the presence of polyglucosan inclusion bodies (Lafora bodies) in brain and other tissues. Genetically engineered mice lacking expression of either the laforin (Epm2a(-/-) ) or malin (Epm2b(-/-) ) genes...

Journal: :Experimental neurology 2013
Masatomo Watanabe Asuka Miyai Sonoko Danjo Yu Nakamura Kouichi Itoh

Alterations in the NO pathway play an important role in the development of convulsive seizures via the glutamatergic and GABAergic systems in acute pentylenetetrazole (PTZ) seizure animals. We previously reported that the background NO levels under physiological conditions negatively regulate convulsive seizures, while excess NO levels under pathologic conditions positively regulate PTZ-induced...

Journal: :Epilepsy & Behavior 2012
Daniel de Castro Medeiros Vinícius Rosa Cota Maura Regina Silva da Páscoa Vilela Flávio Afonso Gonçalves Mourão André Ricardo Massensini Márcio Flávio Dutra Moraes

In the PTZ animal model of epilepsy, electrical stimulation applied to the amygdaloid complex may result in either pro-convulsive or anticonvulsant effect, depending on the temporal pattern used (i.e. periodic-PS and non-periodic-NPS electrical stimulation). Our hypothesis is that the anatomical target is a determinant factor for the differential effect of temporally-coded patterns on seizure o...

2012
Majid Asadi-Shekaari Taj Pari Kalantaripour Fatemeh Arab Nejad Elaheh Namazian Azam Eslami

BACKGROUND Epilepsy is a chief communal health problem. Antiepileptic drugs only provide symptomatic treatment. Walnut Kernels (WK) have high concentrations of phenolic compounds, which have beneficial effects on human health because of their antioxidant and anti-atherogenic properties. The present study was designed to evaluate the efficacy of WK supplementation for the prevention of experimen...

Journal: :physiology and pharmacology 0
abdolkarim hosseini department of physiology, faculty of biological science, shahid beheshti university, tehran, iran naser mirazi department of biology, faculty of basic science, bu-ali sina university, hamedan, iran ali gomar department of biology, science & research institute, islamic azad university, tehran, iran

introduction: there is evidence that diabetes affects seizure susceptibility. ginger (zingiber officinale roscoe) which is used in traditional medicine has antioxidant activity and neuroprotective effects. the aim of this study was to evaluate the seizure threshold induced by pentylenetetrazole (ptz) in diabetic mice after induction of diabetes with streptozocin and to examine the possible role...

Journal: :Seizure 2010
Giangennaro Coppola Salvatore Arcieri Alfredo D’Aniello Tullio Messana Alberto Verrotti Giuseppe Signoriello Antonio Pascotto

Despite anticonvulsant efficacy in animal models of generalized epilepsy, levetiracetam was not effective in the maximal subcutaneous PTZ model in mice and rats. Aim of this study was to assess the efficacy of levetiracetam (LEV) against submaximal, s.c. MET test (PTZ at the dose of 70 mg/kg) acute seizures in Wistar rats, in comparison to valproic acid (VPA). Thirty male Wistar rats (P42) were...

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