نتایج جستجو برای: PTPN22

تعداد نتایج: 605  

2013
Marianne R. Spalinger Silvia Lang Stephan R. Vavricka Michael Fried Gerhard Rogler Michael Scharl

BACKGROUND Variations within the gene locus encoding protein tyrosine phosphatase non-receptor type 22 (PTPN22) are associated with the risk to develop inflammatory bowel disease (IBD). PTPN22 is involved in the regulation of T- and B-cell receptor signaling, but although it is highly expressed in innate immune cells, its function in other signaling pathways is less clear. Here, we study whethe...

2017
Giuseppe Galvani Georgia Fousteri

An allelic variant of the protein tyrosin phosphatase non-receptor 22 (PTPN22) gene, PTPN22 R620W, constitutes the strongest non-HLA genetic risk factor for the development of type 1 diabetes (T1D). A number of studies using mouse models have addressed how PTPN22 predisposes to T1D. PTPN22 downmodulation, overexpression or expression of the variant gene in genetically manipulated mice has gener...

2014
Hui-Hsin Chang William Tseng Jing Cui Karen Costenbader I-Cheng Ho

INTRODUCTION A C-to-T single nucleotide polymorphism (SNP) located at position 1858 of human protein tyrosine phosphatase, non-receptor type 22 (PTPN22) complementary DNA (cDNA) is associated with an increased risk of systemic lupus erythematosus (SLE). How the overall activity of PTPN22 is regulated and how the expression of PTPN22 differs between healthy individuals and patients with lupus ar...

2013
Peilin Zheng Stephan Kissler

PTPN22 encodes the lymphoid tyrosine phosphatase (LYP) and is the second strongest non-HLA genetic risk factor for type 1 diabetes. The PTPN22 susceptibility allele generates an LYP variant with an arginine-to-tryptophan substitution at position 620 (R620W) that has been reported by several studies to impart a gain of function. However, a recent report investigating both human cells and a knock...

2017
Tatiana Jofra Giuseppe Galvani Mirela Kuka Roberta Di Fonte Bechara G. Mfarrej Matteo Iannacone Shahram Salek-Ardakani Manuela Battaglia Georgia Fousteri

A genetic variant of the protein tyrosine phosphatase non-receptor 22 (PTPN22) is associated with a wide range of autoimmune diseases; however, the reasons behind its prevalence in the general population remain not completely understood. Recent evidence highlights an important role of autoimmune susceptibility genetic variants in conferring resistance against certain pathogens. In this study, w...

Journal: :Immunology and cell biology 2017
Tatiana Jofra Roberta Di Fonte Tarun Edgar Hutchinson Farhad Dastmalchi Giuseppe Galvani Manuela Battaglia Shahram Salek-Ardakani Georgia Fousteri

PTPN22 (protein tyrosine phosphatase non receptor 22) encodes a tyrosine phosphatase that functions as a key regulator of immune homeostasis. In particular, PTPN22 inhibits T-cell receptor signaling and selectively promotes type I interferon responses in myeloid cells. To date, there is little information on the CD8 T-cell-intrinsic role of PTPN22 in response to a viral pathogen. We unexpectedl...

2016
Xiaotian Lin Stephane Pelletier Sebastien Gingras Stephanie Rigaud Christian J. Maine Kristi Marquardt Yang D. Dai Karsten Sauer Alberto R. Rodriguez Greg Martin Sergey Kupriyanov Ling Jiang Liping Yu Douglas R. Green Linda A. Sherman

An allelic variant of protein tyrosine phosphatase nonreceptor type 22 (PTPN22), PTPN22(R620W), is strongly associated with type 1 diabetes (T1D) in humans and increases the risk of T1D by two- to fourfold. The NOD mouse is a spontaneous T1D model that shares with humans many genetic pathways contributing to T1D. We hypothesized that the introduction of the murine orthologous Ptpn22(R619W) muta...

2016
Sonja Vermeren Katherine Miles Julia Y Chu Donald Salter Rose Zamoyska Mohini Gray

Neutrophils act as a first line of defense against bacterial and fungal infections, but they are also important effectors of acute and chronic inflammation. Genome-wide association studies have established that the gene encoding the protein tyrosine phosphatase nonreceptor 22 (PTPN22) makes an important contribution to susceptibility to autoimmune disease, notably rheumatoid arthritis. Although...

Journal: :The Journal of clinical investigation 2011
Laurence Menard David Saadoun Isabelle Isnardi Yen-Shing Ng Greta Meyers Christopher Massad Christina Price Clara Abraham Roja Motaghedi Jane H Buckner Peter K Gregersen Eric Meffre

Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene polymorphisms are associated with many autoimmune diseases. The major risk allele encodes an R620W amino acid change that alters B cell receptor (BCR) signaling involved in the regulation of central B cell tolerance. To assess whether this PTPN22 risk allele affects the removal of developing autoreactive B cells, we tested by ELISA ...

2016
Jiaying Deng Junhua Zhang Chunyu Wang Qing Wei Daizhan Zhou Kuaile Zhao

Esophageal squamous cell carcinoma (ESCC) is a fatal disease contributed by both genetic and epigenetic factors. The epigenetic alteration of protein tyrosine phosphatase non-receptor type 22 (PTPN22) and its clinical significance in ESCC were still not yet clarified. A quantitative methylation study of PTPN22 and its expression were conducted in 121 and 31 paired tumor and adjacent normal tiss...

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