A regional climate model named Providing REgional Climates for Impacts Studies (PRECIS) adapted in generating rainfall scenarios for the SAARC (South Asian Association for Regional Cooperation) region. At first, PRECIS generated rainfall scenario is calibrated with ground-based observed rainfall during baseline period (1961-1990) in Bangladesh. The regression coefficients obtained through calib...

To evaluate the intervention effects of randomized controlled trials (RCT) involved in theoretical efficacy and actual clinical outcome (effectiveness). Pragmatic-Explanatory Continuum Indicator Summary (PRECIS) is a tool to help researchers make decisions in study design which is consistent with the intended purpose of their trial which can be used in the design of RCT to balance the internal ...

Results Brainstorming sessions identified the PRECIS presentation (a wheel), lack of a scoring system and domain weighting as issues for exploration in the Delphi process. Thirty four completed responses from 90 invitees were received in Round 1 of the Delphi; Round 2 involved 23 individuals (response rate 82%). 45% selected a 1-5 Likert scale, 56.5% wanted to use a table (to justify decisions)...

BACKGROUND The pragmatic-explanatory continuum indicator summary version 2 (PRECIS-2) tool has recently been developed to classify randomized clinical trials (RCTs) as pragmatic or explanatory based on their design characteristics. Given that treatment effects in explanatory trials may be greater than those obtained in pragmatic trials, conventional meta-analytic approaches may not accurately a...

BACKGROUND If you want to know which of two or more healthcare interventions is most effective, the randomised controlled trial is the design of choice. Randomisation, however, does not itself promote the applicability of the results to situations other than the one in which the trial was done. A tool published in 2009, PRECIS (PRagmatic Explanatory Continuum Indicator Summaries) aimed to help ...

INTRODUCTION There has been increasing interest in pragmatic trials methodology. As a result, tools such as the Pragmatic-Explanatory Continuum Indicator Summary-2 (PRECIS-2) are being used prospectively to help researchers design randomised controlled trials (RCTs) within the pragmatic-explanatory continuum. There may be value in applying the PRECIS-2 tool retrospectively in a systematic revie...

Precis: Three general elections were held for the Northern Ireland Parliament during the 1920s. The 1921 and 1925 elections were contested using proportional representation, whereas the 1929 elec­ tions used the "first-past-the-post system". This paper analyses how the change in the electoral system reversed the trend towards political plurality reflected in the 1925 election results, and facil...

For results from a randomised trial to be relevant to practice it is important that the needs of the end users of the trial, health care professionals, policymakers and patients are considered. Key aspects of a trial need to reflect how the intervention would be implemented. PRECIS-2 is an innovative way to display information about a trial’s design, using a wheel with 9 spokes or domains, grap...

Conclusion: consider changing "highlights the potential usefulness" of PRECIS-2. Authors: We have revised this section of the abstract completely. Introduction P1 line 38 Spelling Loudon instead of Ludon Authors: This is now addressed P2 line 53, [24] reference to Cochrane review Authors: This is now addressed Method p1 2.1 Line 13 need to insert references [13] [14] Authors: Addressed Method P...

BACKGROUND The Pragmatic-Explanatory Continuum Indicator Summary (PRECIS) tool is intended to be used in the design phase of trials to help investigative teams design trials in-line with their purpose. Our team applied this tool to an ongoing trial (BLISTER) to determine whether the initial suggestion among some team members that the trial could be described as largely pragmatic was the consens...