نتایج جستجو برای: PPAR-γ

تعداد نتایج: 81065  

Hossein Babaahmadi Rezaei, Mahdi Aminian, Mahmood Doosti, Parisa Shabani,

Background: There is evidence that CD36 promotes foam cell formation through internalizing oxidized LDL (ox-LDL) into macrophages therefore, it plays a key role in pathogenesis of atherosclerosis. In addition, CD36 expression seems to be mediated by nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-γ). The aim of the present study was to evaluate and compare the effect of ...

Journal: :basic and clinical neuroscience 0
shahnaz babaei abraki parnian eslami fariba khodagholi

introduction: the inflammatory response requires a coordinated integration of various signaling pathway including cyclooxygenase (cox). cox catalyzes the formation of prostaglandins from arachidonic acid. among prostaglandins, 15-deoxy-d12, 14-prostaglandin j2 (15d-pgj2), an endogenous ligand of peroxisome proliferator-activated receptor-gamma (ppar-γ), has been demonstrated to have anti-inflam...

Fariba Khodagholi, Parnian Eslami, Shahnaz Babaei Abraki,

Introduction: The inflammatory response requires a coordinated integration of various signaling pathway including cyclooxygenase (COX). COX catalyzes the formation of prostaglandins from arachidonic acid. Among prostaglandins, 15-Deoxy-D12, 14-prostaglandin J2 (15d-PGJ2), an endogenous ligand of Peroxisome proliferator-activated receptor-gamma (PPAR-γ), has been demonstrated to have anti-inflam...

Journal: :iranian biomedical journal 0
حسین بابا احمدی رضایی hossein babaahmadi rezaei محمود دوستی mahmood doosti مهدی امینیان mahdi aminian پریسا شعبانی parisa shabani

background: there is evidence that cd36 promotes foam cell formation through internalizing oxidized ldl (ox-ldl) into macrophages therefore, it plays a key role in pathogenesis of atherosclerosis. in addition, cd36 expression seems to be mediated by nuclear receptor peroxisome proliferator-activated receptor gamma (ppar-γ). the aim of the present study was to evaluate and compare the effect of ...

Journal: :journal of research in medical sciences 0
fatemeh namvaran department of pharmacology, school of medicine, iran university of medical sciences, tehran and transplant research center, shiraz university of medical sciences, shiraz, iran. parvaneh rahimi-moghaddam department of pharmacology, college of medicine, iran university of medical sciences, tehran, iran. negar azarpira transplant research center, shiraz university of medical sciences, shiraz, iran.

background: the peroxisome proliferator-activated receptor-γ (ppar-γ) is a nuclear hormone receptor. it is predominantly expressed in adipose tissue and as a receptor for thiazolidinediones, it has drawn attentions towards itself as a key molecule to trigger pathways involving in some diseases such as cancers, type 2 diabetes, inflammations and osteoporosis. a proline changed to alanine in codo...

Journal: :genetics in the 3rd millennium 0
خدیجه شبانی khadijeh shabani biology department, school of science, university of isfahan, iran. کامران قائدی kamran ghaedi biology department, school of science, university of isfahan, iran محمد حسین نصر اصفهانی mohammad hossein nasr esfahani nasr esfahani department of cell and molecular biology, royan institute for animal biotechnology, acecr, isfahan, iran سمیه تنهایی somayeh tanhaei department of cell and molecular biology, royan institute for animal biotechnology, acecr, isfahan, iran خدیجه کربلایی khadijeh karbalaei department of cell and molecular biology, royan institute for animal biotechnology, acecr, isfahan, iran صادق ولیان sadegh vallian biology department, school of science, university of isfahan, iran

mouse embryonic stem cells (es) are pluripotent cell lines derived from the inner cell mass of the blastocyst. their properties include self renewal and capacity to differentiate into different cell types. neural differentiation of es cells has been achieved by several different protocols such as treating with retinoic acid and serum decreasing in culture media. the ppars (peroxisome proliferat...

2014
Abhita Malaviya Paul W Sylvester

Previous findings showed that the anticancer effects of combined γ -tocotrienol and peroxisome proliferator activated receptor γ (PPAR γ ) antagonist treatment caused a large reduction in PPAR γ expression. However, other studies suggest that the antiproliferative effects of γ -tocotrienol and/or PPAR γ antagonists are mediated, at least in part, through PPAR γ -independent mechanism(s). Studie...

Journal: :journal of research in medical sciences 0
parizad taraghijou students' research committee,department of nutrition, tabriz university of medical science, tabriz, iran abdolrasoul safaeiyan departments of vital statistics and epidemiology, tabriz university of medical science, tabriz, iran majid mobasseri medicine, endocrinology and metabolism section, imam reza hospital , tabriz university of medical science, tabriz, iran alireza ostadrahimi nutrition research center, tabriz university of medical science, tabriz, iran

background : peroxisome proliferator-activated receptor gamma (ppar γ) is a transcription factor, which is abundantly expressed in adipose tissue and has a direct link to adiposity. it seems that long-chain polyunsaturated fatty acids (lc-pufas) can regulate ppar γ expression. the purpose of this study was to investigate the effects of n-3lc pufa supplementation on plasma levels of ppar γ and t...

2010
Cristen Chafin Sarah Muse Raquel Hontecillas Josep Bassaganya-Riera David L Caudell Samuel K Shimp M Nichole Rylander John Zhang Liwu Li Christopher M Reilly

Activation of the nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPAR-γ) has been shown to be immunoregulatory in autoimmune diseases by inhibiting production of a number of inflammatory mediators. We investigated whether PPAR-γ gene deletion in hematopoietic cells would alter disease pathogenesis in the antiglomerular basement membrane (anti-GBM) mouse model. PPAR-γ...

Alzheimer’s disease (AD) is undoubtedly one of the serious and growing public health challenges in the world today. There is an unmet need for new and effective preventative and therapeutic treatment approaches for AD, particularly at early stages of the disease. However, the underlying mechanism against Aβ-induced electrophysiological alteration in cultured hippocampal pyramidal neurons  is st...

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