Objective The aim of present study was to clarify the role of the peroxisome proliferator-activated receptor (PPAR) γ Pro12Ala and C161T polymorphisms in the pathogenesis of polycystic ovary syndrome (PCOS) and their influence on lipid and lipoprotein profiles of patients. MaterialsAndMethods The present cross-sectional study consisted of 50 women with PCOS, who referred to the Kermanshah Unive...

mast cells play an important role in a variety of inflammatory diseases, particularly asthma and atopy. peroxisome proliferator-activated receptor gamma (pparγ) is a member of the large nuclear hormone  receptor  transcription  factor  superfamily, and  has  been  recently implicated in the anti-inflammatory response. to investigate a possible role for pparγ in human mast cells, we studied the ...

TH9 cells, a subpopulation of TH2 are crucial mediators allergic skin inflammation. They characterized by expression IL-9/IL-9R and rely on the transcription factor PPARγ for full effector function. The functional role in however, remains unknown. Pathway analysis RNA-seq data from PPARγ-inhibited cells revealed concerted downregulation genes associated with T cell activation, glucose metabolis...

PPAR (peroxisome-proliferator-activated receptor) γ is expressed in brown and white adipose tissues and is involved in the control of differentiation and proliferation. Noradrenaline stimulates brown pre-adipocyte proliferation and brown adipocyte differentiation. The aim of the present study was thus to investigate the influence of noradrenaline on PPARγ gene expression in brown adipocytes. In...

The 70% ethanol extract of Artemisia campestris was screened to find PPARγ ligands using the ligand-responsive chimera luciferase reporter system. Capillartemisin B identified as a ligand that stimulated lipid accumulation in 3T3-L1 cells. By further purification from large-scale preparation methanol campestris, we isolated and eupatilin santaflavone ligands. Weak activity or assay enhanced by ...

Peroxisome proliferator-activated receptor γ (PPARγ) is a key transcription factor in mammalian adipogenesis. Genome-wide approaches have identified thousands of PPARγ binding sites in mouse adipocytes and PPARγ upregulates hundreds of protein-coding genes during adipogenesis. However, no microRNA (miRNA) genes have been identified as primary PPARγ-targets. By integration of four separate datas...

Transforming growth factor β1 (TGFβ1) promotes fibrosis by, among other mechanisms, activating quiescent fibroblasts into myofibroblasts and increasing the expression of extracellular matrices. Recent work suggests that peroxisome proliferator-activated receptor γ (PPARγ) is a negative regulator of TGFβ1-induced fibrotic events. We, however, hypothesized that antifibrotic pathways mediated by P...

PURPOSE Previous reports suggest that age-related meibomian gland atrophy is associated with decreased expression of the lipid-sensitive nuclear receptor, PPARγ. The purpose of this study was to identify the role of PPARγ in modulating meibocyte lipid synthesis. METHODS Cytoplasmic and nuclear fractions from meibomian glands of young (2M) and old (2Y) C57Bl6 mice were probed using antibodies ...

OBJECTIVE Peroxisome proliferator-activated receptor γ (PPARγ) is widely expressed in vessel walls, and it's activation by agonists showed beneficial effects in cardiovascular diseases. However, the role of endothelial cell (EC) PPARγ in atherogenesis is not fully understood. METHODS AND RESULTS To assess the contribution of endothelial-specific PPARγ in atherosclerosis, EC-specific PPARγ dis...

Peroxisome proliferator-activated receptor γ2 (PPARγ) is a nuclear transcription factor that regulates adipocyte differentiation and lipogenic genes during adipogenesis. The activity of rodent PPARγ is regulated by phosphorylation of serine 112. The current experiment was designed to study the ability of porcine PPARγ to stimulate transdifferentiation of myoblasts to adipocytes by overexpressin...