نتایج جستجو برای: PNDM

تعداد نتایج: 79  

2015
Zhenhong Chen Hongxia Li Jiao Feng Yuxue Li Xin Chen Xuemin Guo Weijun Chen Li Wang Lei Lin Huiying Yang Wenhui Yang Jie Wang Dongsheng Zhou Changting Liu Zhe Yin

A carbapenem-nonsusceptible Enterobacter aerogenes strain named 3-SP was isolated from a human case of pneumonia in a Chinese teaching hospital. NDM-1 carbapenemase is produced by a pNDM-BJ01-like conjugative plasmid designated p3SP-NDM to account for carbapenem resistance of 3-SP. p3SP-NDM was fully sequenced and compared with all publically available pNDM-BJ01-like plasmids. The genetic diffe...

Journal: :Diabetes 2006
Chia-Wei Lin Yu-Wen Lin Fei-Fei Yan Jillene Casey Malini Kochhar Emily B Pratt Show-Ling Shyng

Heterozygous missense mutations in the pore-forming subunit Kir6.2 of ATP-sensitive K(+) channels (K(ATP) channels) have recently been shown to cause permanent neonatal diabetes mellitus (PNDM). Functional studies demonstrated that PNDM mutations reduce K(ATP) channel sensitivity to ATP inhibition, resulting in gain of channel function. However, the impact of these mutations on channel expressi...

Journal: :Antimicrobial agents and chemotherapy 2015
Lim S Jones Maria J Carvalho Mark A Toleman P Lewis White Thomas R Connor Ammara Mushtaq Janis L Weeks Karthikeyan K Kumarasamy Katherine E Raven M Estée Török Sharon J Peacock Robin A Howe Timothy R Walsh

The blaNDM-1 gene is associated with extensive drug resistance in Gram-negative bacteria. This probably spread to Enterobacteriaceae from Acinetobacter spp., and we characterized plasmids associated with blaNDM-1 in Acinetobacter spp. to gain insight into their role in this dissemination. Four clinical NDM-1-producing Acinetobacter species strains from India and Pakistan were investigated. A pl...

Journal: :The Journal of antimicrobial chemotherapy 2015
Bing Wang Dongchang Sun

Sir, Recently, a new carbapenemase, NDM-1, encoded by blaNDM-1, has become a global concern. Previous work reported the prevalence of blaNDM-1 mainly in animal-associated and human-associated bacteria (e.g. patients and animals – ). Walsh et al. detected blaNDM-1 in seepage samples and drinking water, indicating the dissemination of blaNDM-1 in the environment. Soil, one of the largest natural ...

2015
Adriana Mangue Esquiaveto-Aun Maricilda Palandi De Mello Maria Fernanda Vanti Macedo Paulino Walter José Minicucci Gil Guerra-Júnior Sofia Helena Valente De Lemos-Marini

BACKGROUND Permanent neonatal diabetes mellitus (PNDM) is a rare disorder, characterized by uncontrolled hyperglycemia diagnosed during the first 6 months of life. In general, PNDM has a genetic origin and most frequently it results from heterozygous mutations in KCNJ11, INS and ABCC8 genes. Homozygous or compound heterozygous inactivating mutations in GCK gene as cause of PNDM are rare. In con...

2014
Ke Huang Li Liang Jun-feng Fu Guan-pin Dong

BACKGROUND Permanent neonatal diabetes mellitus (PNDM) is a rare disease, which is defined as the onset of diabetes before the age of 6 months with persistence through life. Infants with KCNJ11 or ABCC8 genetic mutations may respond to oral sulfonylurea therapy. Currently, there are limited studies about the genetic analysis and long-term follow-up of PNDM. CASE PRESENTATION We report four ca...

2015
Shuru Zhou Xin Chen Xiaobin Meng Guoxiong Zhang Jie Wang Dongsheng Zhou Xuemin Guo

Acinetobacter pittii 44551 was recovered from a patient with gout combined with tuberculosis and was found to harbor the carbapenemase genes blaNDM-1 and blaOXA-58 on two different plasmids pNDM-44551 and pOXA58-44551, respectively. pNDM-44551 displayed high self-transferability across multiple bacterial species, while pOXA58-44551 was likely co-transferable with pNDM-44551 into A. baumannii re...

2015
Anirban Sarkar Gururaja P. Pazhani Goutam Chowdhury Amit Ghosh Thandavarayan Ramamurthy

A carbapenem resistant Salmonella enterica serovar Senftenberg isolate BCH 2406 was isolated from a diarrheal child attending an outpatient unit of B.C. Roy Hospital in Kolkata, India. This isolate was positive for the bla NDM-1 in the PCR assay, which was confirmed by amplicon sequencing. Except for tetracycline, this isolate was resistant to all the tested antimicrobials. The bla NDM-1 was fo...

2013
James S. McTaggart Ned Jenkinson John-Stuart Brittain Siri A. W. Greeley Andrew T. Hattersley Frances M. Ashcroft

BACKGROUND Gain-of-function mutations in the ATP-sensitive potassium channel can cause permanent neonatal diabetes mellitus (PNDM) or neonatal diabetes accompanied by a constellation of neurological symptoms (iDEND syndrome). Studies of a mouse model of iDEND syndrome revealed that cerebellar Purkinje cell electrical activity was impaired and that the mice exhibited poor motor coordination. In ...

2012
Banu Küçükemre Ay Rüveyde Bundak Firdevs Baş Hülya Maraş Nurçin Saka Hülya Günöz Feyza Darendeliler

Permanent neonatal diabetes mellitus (PNDM) is a rare condition presenting before six months of age. Mutations in the genes encoding the ATP-sensitive potassium (KATP) channel are the most common causes. Sulfonylurea (SU) therapy leads to dramatic improvement in diabetes control and quality of life in most patients who carry these mutations. Here, we report the long-term follow-up results of tw...

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