BACKGROUND Clinical trials have revealed that the antivascular endothelial growth factor (VEGF) therapies are effective in retinopathy of prematurity (ROP). But the low level of VEGF was necessary as a survival signal in healthy conditions, and endogenous placental growth factor (PIGF) is redundant for development. The purpose of this study was to elucidate the PIGF expression under hypoxia as ...

Placenta growth factor (PIGF), an angiogenic factor belonging to the vascular endothelial growth factor family, pregnancy-associated plasma protein A (PAPP-A) and free beta-human chorionic gonadotrophin (beta-hCG) were measured in maternal serum from 45 pregnancies with trisomy 21, 45 with trisomy 18 and 493 normal controls at 10-13 completed weeks of gestation. In the normal pregnancies matern...

BACKGROUND Insulin-like growth factor I (IGF-I) is one important family of growth factors, which plays key role in intestinal growth, regeneration, and damage repair. However, the low natural abundance of IGF-I limits its research opportunities and practical application in the fields of medicine and animal husbandry. In this study, a tandem repeat strategy was used to express three copies of th...

We aimed to investigate the correlation between placental growth factor (PIGF) expression in placenta of preeclampsia (PE) patients and PE symptoms. Between June 2013 and June 2015, a total of 141 placenta samples were selected from 141 gravidas who delivered in The Second Hospital of Hebei Medical University. Among 141 gravidas, 50 healthy gravidas were regarded as the control group, 45 gravid...

Vascular endothelial growth factor (VEGF) and placenta growth factor (PIGF) are members of a dimeric-growth-factor family with angiogenic properties. VEGF is a highly potent and specific mitogen for endothelial cells, playing a vital role in angiogenesis in vivo. The role of PIGF is less clear. We expressed the monomeric splice forms VEGF-165, VEGF-121, PIGF-1 and PIGF-2 as unfused genes in Esc...

Placenta Growth Factor (PIGF) is a new member of vascular endothelial growth factor (VEGF) family. Although VEGF binds FIt family Fit-I and KDR/FIk-I tyrosine kinases at high affinity for signal transduction, biological activities and the receptors of PIGF have not been extensively studied. Reverse transcription-PCR showed that P1GF-2, a subtype of PIGF-I that bears a basic amino acid-rich doma...

The prognostic value of angiogenic factors in newly pregnant women with obstetric antiphospholipid syndrome (oAPS) has not been documented. We observed 513 oAPS who experienced three consecutive spontaneous abortions before the 10th week of gestation or one fetal loss at or beyond the 10th week. We assessed the plasma concentrations of the proangiogenic factor placenta growth factor (PIGF) and ...

Introduction . Fractures of the maxilla are characterized by such features as close location vital anatomical structures, visual organ, well aesthetic importance this area face and presence risk serious complications. The aim work was to estimate level angiogenic factors in oral fluid: vascular endothelial growth factor A (VEGF-A), D (VEGF-D), placental (PIGF), platelet-derived BB (PDGF-BB) (VE...

Preeclampsia is an obstetric disease that a health problem worldwide, including in Indonesia. Several studies have shown changes the maternal spiral arteries are thought to lead preeclampsia. this decade has been associated with angiogenesis regulatory proteins originating from placenta and circulating mother's blood circulation, namely soluble FMS-like tyrosine kinase 1 (sFlt-1) placental grow...

Serum concentrations of three angiogenic cytokines: vascular endothelial growth factor (VEGF), stromal cell-derived factor-1 (SDF-1) and placental growth factor (PIGF) and soluble vascular cell adhesion molecule 1 (sVCAM-1), were investigated in the serum of 61 patients with systemic lupus erythematosus (SLE) and 20 healthy subjects. The possible association between serum levels of these protei...