نتایج جستجو برای: PGK1

تعداد نتایج: 237  

2013
Helen M. Ameis Astrid Drenckhan Katharina von Loga Gabriele Escherich Katharina Wenke Jakob R. Izbicki Konrad Reinshagen Stephanie J. Gros

BACKGROUND AND AIM A close relationship between phosphoglycerate kinase 1 (PGK1) and the CXCR4/SDF1 axis (chemokine receptor 4/stromal cell derived factor 1) has been shown for several cancers. However, the role of PGK1 has not been investigated for neuroblastoma, and PGK1 might be a therapeutic target for this tumor entity. The aim of the current study was to evaluate the role of PGK1 expressi...

2015
Shiwen Wang Bowen Jiang Tengfei Zhang Lixia Liu Yi Wang Yiping Wang Xiufei Chen Huaipeng Lin Lisha Zhou Yukun Xia Leilei Chen Chen Yang Yue Xiong Dan Ye Kun-Liang Guan Daniel Durocher

Phosphoglycerate kinase 1 (PGK1) catalyzes the reversible transfer of a phosphoryl group from 1, 3-bisphosphoglycerate (1, 3-BPG) to ADP, producing 3-phosphoglycerate (3-PG) and ATP. PGK1 plays a key role in coordinating glycolytic energy production with one-carbon metabolism, serine biosynthesis, and cellular redox regulation. Here, we report that PGK1 is acetylated at lysine 220 (K220), which...

Journal: :International journal of cancer 2010
Derek Zieker Ingmar Königsrainer Isabel Tritschler Markus Löffler Stefan Beckert Frank Traub Kay Nieselt Sarah Bühler Michael Weller Jochen Gaedcke Russell S Taichman Hinnak Northoff Björn L D M Brücher Alfred Königsrainer

Peritoneal carcinomatosis is a frequent finding in gastric cancer associated with a poor prognosis. The features that enable gastric tumors to disseminate are poorly understood until now. Previously, we showed elevated mRNA levels of phosphoglycerate kinase 1 (PGK1), an adenosine triphosphate-generating enzyme in the glycolytic pathway, the chemokine receptor 4 (CXCR4), the corresponding chemok...

2016
Junbao Yang Yongsheng Xiang Linghui Liu Xiangyu Wang

Phosphoglycerate kinase 1 (PGK1), a glycolytic enzyme, is overexpressed in several carcinomas and plays an important role in their malignancy. However, expression and function of PGK1 in gliomas are unknown. In the present study, we determined PGK1 protein expression in different World Health Organization (WHO) grade glioma tissues and normal brain tissues by performing immunohistochemical anal...

2017
Huijun Xie Guihui Tong Yupei Zhang Shu Liang Kairui Tang Qinhe Yang

During the proliferation and metastasis, the tumor cells prefer glycolysis (Warburg effect), but its exact mechanism remains largely unknown. In this study, we demonstrated that phosphoglycerate kinase 1 (PGK1) is an important enzyme in the pathway of metabolic glycolysis. We observed a significant overexpression of PGK1 in hepatocellular carcinoma tissues, and a correlation between PGK1 expres...

2017
Wenbo Sun Hua Yan Chunfa Qian Chenhan Wang Mengjie Zhao Yuchi Liu Yujie Zhong Hongyi Liu Hong Xiao

Glioma is a primary malignancy in central nervous system. Radiotherapy has been used as one of the standard treatments for glioma for decades. Since radioresistance can reduce the curative efficacy of radiotherapy in glioma, investigating the cause of radioresistance and predicting the tumour radiosensibility appeared particularly important. We previously reported that CFL1 and PGK1 are over-ex...

Journal: :Molecular cancer research : MCR 2009
Younghun Jung Yusuke Shiozawa Jianhua Wang Jingcheng Wang Zhuo Wang Elisabeth A Pedersen Clara H Lee Christopher L Hall Phillip J Hogg Paul H Krebsbach Evan T Keller Russell S Taichman

Prostate cancer (PCa) is one of the solid tumors that metastasize to the bone. Once there, the phenotype of the bone lesions is dependent upon the balance between osteoblastogenesis and osteoclastogenesis. We previously reported that overexpression of phosphoglycerate kinase 1 (PGK1) in PCa cell lines enhanced bone formation at the metastatic site in vivo. Here, the role of PGK1 in the bone for...

Journal: :Oncology reports 2014
Hao Ding Yi-Jun Cheng Hua Yan Rui Zhang Jin-Bing Zhao Chun-Fa Qian Wen-Bin Zhang Hong Xiao Hong-Yi Liu

Phosphoglycerate kinase 1 (PGK1) has been found to be increased in radioresistant astrocytomas. The present study was designed to investigate the potential role of PGK1 in the radioresistance in U251 human cells. Quantitative PCR and western blot analysis were performed to evaluate PGK1 expression for mRNA levels and protein levels, respectively. The short hairpin RNA (shRNA)-PGK1 and the high ...

Journal: :International journal of oncology 2013
Sufian S Ahmad Jörg Glatzle Khaled Bajaeifer Sarah Bühler Thorsten Lehmann Ingmar Königsrainer Jörg-Peter Vollmer Bence Sipos Suhaib S Ahmad Hinnak Northoff Alfred Königsrainer Derek Zieker

Oxidative stress due to intratumoral hypoxia in solid cancer has been shown to be associated with increased mortality. Phosphoglycerate kinase 1 (PGK1) is an enzyme of the glycolytic pathway, which is regulated by hypoxia-inducible factor-1α (HIF-1α) and has been described for its role in tumor progression and metastasis in several malignancies. We investigated whether the expression of PGK1 va...

2015
Wei Lu Jian Gao Jingyun Yang Yang Cao Lin Jiang Maolan Li Yijian Zhang Jian Zhou Yingbin Liu

To evaluate prognostic significance of phosphoglycerate kinase 1 (PGK1) protein expression in patients with gallbladder cancer (GBC).Ninety-five patients who underwent surgical resection for GBC between January 2004 and December 2010 were enrolled. Overall survival (OS) and disease-free survival (DFS) were evaluated over a 10-year follow-up. PGK1 expression was assessed by tissue microarray and...

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