Introduction Thyroid cancer is a malignant disease with poor prognosis. The PI3K/Akt/mTOR and Cyclin-Dependent Kinase 4 (CDK4) pathways are vital regulators of tumor cell proliferation and survival. Therefore the present study was designed to use dual inhibition of such pathways to kill thyroid cancer cells. Methods and materials The effects of each inhibitors on human ATC and...

Introduction Thyroid cancer is a malignant disease with poor prognosis. The PI3K/Akt/mTOR and Cyclin-Dependent Kinase 4 (CDK4) pathways are vital regulators of tumor cell proliferation and survival. Therefore the present study was designed to use dual inhibition of such pathways to kill thyroid cancer cells. Methods and materials The effects of each inhibitors on human ATC and...

the ball and beam system is one of the most popular laboratory setups for control education. in this paper, we design a fuzzy pd cascade controller for a ball and beam system using asexual reproduction optimization (aro) technique. the ball & beam system consists of a servo motor, a grooved beam, and a rolling ball. this system utilizes a servo motor to control ball’s position on the beam. chan...

objectives to explore the effect of a selective 10-week corrective exercise with an emphasis on gait training activities (gta) on the number of falls (nofs), fear of falling, functional balance, timed up and go (tug) test among pd patients. background posture instability and unsteady gait disorders in parkinson’s disease (pd) usually contribute to fall-related fractures. fall-related trauma in ...

a palladium composite membrane was prepared via electroless plating technique using organic-inorganic method during activation process. the ceramic support surface was modified by two tio2-boehmite and one γ-alumina layers to avoid pd penetration in support pores. thin and defect-free pd composite membrane was obtained by creating a relative smoothness on the ceramic support and using pd nanopa...

programmed cell death-1 (pd-1) and its ligands, pd-l1 and pd-l2, have been regarded as important immune system regulatory molecules. the aberrant expression of the molecules has been related to several autoimmune disorders. this study is aimed to assess the mrna expression level of pd-1, pd-l1, and pd-l2 molecules in the peripheral blood mononuclear mells (pbmcs) from multiple sclerosis (ms) pa...