Palmtop-assisted self-interviewing (PASI) may provide a cheaper and more mobile alternative to audio-computer-assisted self-interviewing (ACASI) for collecting sensitive behavioral data. To evaluate PASI, in late 2002 the authors enrolled 1,283 Thai students aged 15-21 years in a randomized trial. Data collection used PASI, ACASI, self-administered questionnaire, and face-to-face interview in c...

BACKGROUND Severity grading is important for the assessment of psoriasis treatment efficacy. This is most commonly achieved by using the psoriasis area and severity index (PASI), a subjective tool with inherent inter-rater and intra-rater variability. PASI-naive dermatologists require training to properly conduct a PASI assessment. OBJECTIVE In the present study, we aimed to investigate wheth...

Background: Psoriasis is a common skin disease which beneficiated lately from many new drugs, acting on immunity. Phototherapy remains however a cornerstone of treatment in moderate-to-severe forms. Patients exhibit a continuous and longstanding interest in Dead Sea Climatotherapy (DSC), a well-known off-label psoriasis treatment which demonstrated high rates of success since decades. Objective...

chronic plaque-type psoriasis may be difficult to control without the use of potent systemic therapies that are accompanied by systemic toxicity. mycophenolate mofetil is a novel agent that may be effective in the treatment of chronic plaque type psoriasis. our purpose was to investigate of the safety and efficacy of oral mycophenolate mofetil in the treatment of chronic plaque-type psoriasis. ...

INTRODUCTION The Psoriasis Area Severity Index (PASI) is the most widely used scale for assessing the severity of psoriasis and for therapeutic decision making. On the basis of the PASI score, patients have been stratified into 2 groups: mild disease and moderate-to-severe disease. OBJECTIVE To draft a proposal for the definition and characterization of moderate psoriasis based on PASI and De...

Study population The study population comprised a hypothetical cohort of patients with moderate-to-severe psoriasis. Three sub-groups of patients were considered on the basis of disease severity, as represented by two scores, the Psoriasis Area and Severity Index (PASI) and the Dermatology Life Quality Index (DLQI). The three sub-groups were PASI and DLQI greater than 10, PASI and DLQI greater ...

BACKGROUND The Psoriasis Area and Severity Index (PASI) is the score of choice to grade psoriasis severity and detect clinical changes. Due to low resolution based on the calculation of the score by fixed area classes, PASI scores <10 have little value. METHODS At 756 patient examinations, psoriasis activity was measured with both PASI and PrecisePASI. RESULTS PrecisePASI has a linear incre...

The aim of the present study was to examine residues that are variably spliced in the juvenile and adult isoforms of the skeletal-muscle RyR1 (type 1 ryanodine receptor). The juvenile ASI(-) splice variant is less active than the adult ASI(+) variant and is overexpressed in patients with DM (myotonic dystrophy) [Kimura, Nakamori, Lueck, Pouliquin, Aoike, Fujimura, Dirksen, Takahashi, Dulhunty a...

OBJECTIVE The aim of this study was to evaluate functional independence and trunk control during maximum-range tasks in individuals with spinal cord injuries, who were divided into sedentary (SSI, n=10) and physically active (PASI, n=10) groups . METHODS Anamnesis was conducted and level and type of injury were identified (according to the American Spinal Injury Association protocol, ASIA) an...

INTRODUCTION Health-related quality of life (HRQoL) is an important part of the clinical assessment and management of psoriasis. Few studies have investigated the effects of withdrawing treatment on the relationship between HRQoL and objective clinical manifestations of psoriasis. This post hoc subanalysis of a clinical trial (REVEAL) examined the relationship of HRQoL [assessed with the Dermat...