background: malaria is one of the most important parasitic diseases in tropical and temperate regions. the aim of this study was to determine the trend of malaria in mazandaran province, northern iran during 1997-2012. methods: this retrospective study was conducted from 1997 to 2012. the population's study was individuals who registered at health centers of mazandaran province. peripheral bloo...

background: cytoadherence of plasmodium falciparum - infected red blood cells to endothelial cells is an important mechanism for parasite survival and a major trigger for diseases pathology. here, we de­scribe a new adhesion assay in which different cell types (cho, cho/cd36 and cho/icam-1) are at­tached to cytodex beads in a mini-column format to measure the relative sizes of various binding s...

in the course of serological and parasitological studies of malaria, 1,018 persons were examined. they were from four different areas (a, b, c and d) in the region of bandar abbas and 1-1ina), southern iran, where malaria is still endemic. for the serological examinations, the ifat was used with p. falciparum and p.vivax antigens. several fa-positive reactions were observed in young children, m...

Background: Sickle cell disease (HbSS) is a major health problem in Nigeria and ma-laria has been implicated as a leading cause of morbidity/mortality in sickle cell disease patients. Few reasons were put forward to explain the observed morbidity/mortality of HbSS subjects due to Plasmodium falciparum (P. falciparum) malaria. Objectives: To determine the level of immunoglobulin classes (IgM, Ig...

Background: Malaria is still account for 200 million cases annually. Microscopy is the gold standard technique for malaria parasites detection. PCR-based techniques can detect malaria infections with high sensitivity. The study aimed to evaluate the sensitivity of microscopy technique in the detection of P. falciparum and P. vivax, using monoplex real-time PCR, Gezira State, Central Sudan. Met...

background: parasite lactate dehydrogenase ( p ldh) is extensively employed as malaria rapid diagnostic tests (rdts). moreover, it is a well-known drug target candidate. however, the genetic diversity of this gene might influence perfor­mance of rdt kits and its drug target candidacy. this study aimed to determine polymorphism of p ldh gene from iranian isolates of p. vivax and p. falciparum. m...

Mixed malaria infections, Plasmodium falciparum and P. vivax, are suspected to occur at a greater frequency than is detected by conventional light microscopy. In order to determine the year round pattern of transmission and the frequency of mixed infections in malaria endemic area, we carried out a prospective comparison of diagnosis by conventional light microscopy and nested PCR in Chahbahar ...

mixed malaria infections, plasmodium falciparum and p. vivax, are suspected to occur at a greater frequency than is detected by conventional light microscopy. in order to determine the year round pattern of transmission and the frequency of mixed infections in malaria endemic area, we carried out a prospective comparison of diagnosis by conventional light microscopy and nested pcr in chahbahar ...

background: our study aimed at substantiating the recent claim of myo-cardial complications in severe malaria by experimentally inducing severe plasmodium falciparum infection in a humanized mouse model employed as human surrogate. methods: twenty five humanized mice were inoculated with standard in vitro cultured p. falciparum and blood extracts collected from the inner cardiac muscles of infe...