Changes in calcium and redox homeostasis influence multiple cellular processes. Dysregulation of these signaling modalities is associated with pathology in cardiovascular, neuronal, endocrine, and other physiological systems. Calcium and oxidant signaling mechanisms are frequently inferred to be functionally related. To address and clarify this clinically relevant issue in the vasculature we te...

Oxidant injury contributes to acute lung injury (ALI). We previously reported that activation of protein kinase GI (PKGI) posttranscriptionally increased the key antioxidant enzymes catalase and glutathione peroxidase 1 (Gpx-1) and attenuated oxidant-induced cytotoxicity in mouse lung microvascular endothelial cells (MLMVEC). The present studies tested the hypothesis that the antioxidant effect...

Polyaniline/polystyrene (PAni/PS) composites were prepared in aqueous solution by polymerization of styrene and aniline in two-stages. Firstly styrene polymerize by using Ammonium persulfate (APS) as an oxidant in the presence of various surfactants such as poly(vinyl pyrrolidone) (PVP), hydroxypropylcellulose (HPC), poly(vinyl alcohol) (PVA) and surfactive dopant sodium dodecylbenzenesulfonate...

In recent decades, fuel cells have been widely used in energy generation. In a PEMFC, considering the specific application, two types of oxidants are used. Durability tests, which are highly costly products,  are of crucial importance in evaluating the lifetime of fuel cells. The purpose of the present paper is to investigate the performance of a fuel cell by changing the type of oxidant from a...

PURPOSE This study was undertaken to determine whether transient or sustained nonlethal oxidant injury can induce RPE cell membrane blebbing and alter RPE expression of matrix metalloproteinase (MMP)-2 and type IV collagen, two molecules that are necessary for regulation of the turnover of the RPE basal lamina. METHODS The ARPE-19 cell line stably expressing green fluorescent protein (GFP) ta...

diabetes is a common metabolic disease in the world that has many adverse effects. olibanum gum resin (from trees of the genus boswellia) has traditionally been used in the treatment of various diseases such as diabetes. the aim of this study was the comparison of olibanum gum resin effect with placebo on the treatment of type 2 diabetes. inclusion criteria was diabetic patients with fasting bl...

the oxidation of n-pentanol by tetramethylammonium fluorochromate in acidic solution wasstudied using spectrophotometric technique. the reaction was arranged to be under pseudo firstorderconditions respect to the oxidant. a michaelis-menten type kinetic was observed respect tothe substrate. the reaction is catalyzed by hydrogen ions. dependences of the reaction rates ontemperature and different...

keybarkuh area is located 70 km southwest of khaf, khorasan razavi province. the study area is situated in northeastern lut block. the rock units in the area are paleozoic metamorphic rocks and cretaceous to tertiary subvolcanic intrusions intruded as dike, stock and batholith; their composition varies from granite to diorite. based on magnetic susceptibility, the intrusive rocks are divided in...

Objective(s): The present study sought to evaluate the beneficial effects of histidine (His) on oxidative stress, tumor necrosis factor alpha (TNF-α), renal histological alterations and anti-oxidant enzymes gene expressions in type 2 diabetic rats.Materials and Methods: Streptozotocin/nicotinamide (STZ/NA) induced diabetic rats were used...