Results Mean age of patients was 9.6 years. Female: male ratio was 1.5 (F/M=27/18). Oligoarticular JIA was diagnosed in 21 patients, whereas polyarticular JIA and systemic JIA in 17 and in seven patients, respectively. During study period, 23 patients had active disease, while 22 patients were in remission. Mean duration of disease was 2.2 years. Serum ESR, CRP, TOC, TAC and, MPO levels were fo...

Background: Chronic Obstructive Pulmonary Disease (COPD) is a health problem with increasing severity, as exposure to risk factors such as cigarette smoke, pollution is inevitable. Oxidantantioxidant imbalance cause oxidative burden leading to lung tissue damage. Presently, diagnosis of COPD is based on impaired lung function tests. Aims and Objectives: This study was aimed to measure serum lev...

Asthma is characterized by an oxidantantioxidant imbalance in the lungs leading to activation of redox-sensitive transcription factors, nuclear factor kappaB (NF-kappaB), and activator protein-1 (AP-1). To develop therapeutic strategies for asthma, we used a chemogenomics approach to screen for small molecule inhibitor(s) of AP-1 transcription. We developed a beta-strand mimetic template that a...

Pre-clinical and clinical studies have suggested that sleep loss is a predisposing factor for neurodegeneration and memory impairments linked with Alzheimer’s disease (AD) and about 45% of AD patients show sleep disturbances. Sleep deprivation (SD) alters immuno-inflammatory, oxidantantioxidant enzymes balance and brain derived neurotrophic factor (BDNF) pathways which play significant role in ...