Background: To compare the clinical efficacy tranxamic acid and Ibuprofen in the treatment of ovulatory menorrhagia. Materials and Methods: This randomized controlled trial was performed at my office one hundred women with ovulatory hemorrhagic were randomized to take one of two treatment regimens during four consecutive cycles: tranexamic acid 3gr daily on day 1-5, ibuprofen 1200 mg daily. Res...

Up to 14 percent of women experience irregular or excessively heavy menstrual bleeding. This abnormal uterine bleeding generally can be divided into anovulatory and ovulatory patterns. Chronic anovulation can lead to irregular bleeding, prolonged unopposed estrogen stimulation of the endometrium, and increased risk of endometrial cancer. Causes include polycystic ovary syndrome, uncontrolled di...

The levonorgestrel-releasing intrauterine system (LNG-IUS) has proven to be the most effective medical treatment in reducing the amount of menstrual blood loss. However, the molecular mechanisms underlying menorrhagia and/or accounting for the therapeutic effect of the LNG-IUS are still obscure. In this study, we used immunohistochemistry to compare the distribution of sex steroid receptors and...

Endometrial curettings from 458 patients presenting with abnormal uterine bleeding were studied. This included 220 (48%) patients with metrorrhagia, 187 (41%) with menorrhagia, 30 (6%) with postmenopausal bleeding, 13 (3%) with intermenstrual bleeding and 8 (1.74%) with polymenorrhagia. The histological findings were correlated with the pattern of abnormal bleeding in five different age groups....

bnormal uterine bleeding occurs in 9 to 14 percent of women between menarche and menopause, significantly impacting quality of life and imposing financial burden. The etiologies and treatments for abnormal uterine bleeding over the reproductive years are best understood in the context of normal menstrual physiology. A normal cycle starts when pituitary follicle-stimulating hormone induces ovari...

OBSTETRICS & GYNECOLOGY Background Definition and Nomenclature Abnormal uterine bleeding associated with ovulatory dysfunction (AUB-O) (ie, oligo-ovulation or anovulation) is a spectrum of disorders most commonly associated with heavy, irregular uterine bleeding. Abnormal uterine bleeding (AUB) occurs in the setting of ovulatory dysfunction because of the effects of chronic unopposed estrogen o...

The aim of this study was to evaluate the role of lysosomal enzymes in excessively heavy menstruation by comparing women with menorrhagia due to dysfunctional bleeding or intrauterine contraceptive device (IUCD) use with those with normal menstrual periods or with amenorrhoea associated with breastfeeding. This was a prospective cohort investigation of the activity of four endometrial lysosomal...

menorrhagia is one of the most common gynecological problem and leading causes of poor quality of life and iron deficiency anemia in women of reproductive age. research in gynecological field relies heavily on repeated measure designs. repeated measure studies are helpful in understanding how factors of interest change over time. our goal is to apply statistical methods which are appropriate fo...

BACKGROUND Women using progestogen-only contraceptives are commonly troubled by irregular bleeding. Endometrial vessel breakdown and repair is thought to be locally regulated under the indirect influence of sex steroids. Most information about endometrial vessels is derived from blind biopsies taken in an outpatient setting. Hysteroscopy allows in-vivo observation of the whole endometrial surfa...