background: recent studies have demonstrated the high prevalence of vitamin d deficiency in the general population. pregnancy and preterm delivery are known as risk factors for vitamin d deficiency. consequently, vitamin d level in women with preterm deliveries might vary from those with term pregnancies. in this study, we aimed to compare vitamin d level in term and preterm infant–mother pairs...

osteopenia of prematurity (oop) is a preventable disease. improved survival of premature newborns is associated with an increased incidence of oop. the purpose of this study was to compare the prophylactic effects of two low doses of vitamin d (200 and 400 iu/day) on the clinical, biochemical and radiological indices of the rickets of prematurity. in a randomized clinical trial, 60 preterm newb...

BACKGROUND Caffeine, the most commonly used medication in Neonatal Intensive Care Units, has calciuric and osteoclastogenic effects. METHODS To examine the association between the cumulative dose and duration of therapy of caffeine and osteopenia of prematurity, a retrospective cohort study was conducted including premature infants less than 31 weeks and birth weight less than 1500 g. Osteope...

Bone mineral content of the forearm was measured by photon absorptiometry in 17 preterm infants at a postconceptional age of 40 weeks. Radiographs of the forearm were assessed by Koo's method and plasma alkaline phosphatase activity was also measured at this time. Bone mineral content was significantly but weakly correlated with Koo score and was not significantly correlated with alkaline phosp...

prevention and treatment of the rickets of prematurity is an important aspect of the care of preterm infants. the purpose of this study was to compare the prophylactic effects of different doses of vitamin d on the clinical, biochemical and radiological indices of the rickets of prematurity. in a randomized clinical trial, 68 premature infants (<38 weeks) with birth weight under 2000 g, randoml...

Background: Recent studies have demonstrated the high prevalence of vitamin D deficiency in the general population. Pregnancy and preterm delivery are known as risk factors for vitamin D deficiency. Consequently, vitamin D level in women with preterm deliveries might vary from those with term pregnancies. In this study, we aimed to compare vitamin D level in term and preterm infant–mother pairs...

Osteopenia of prematurity and neonatal metabolic bone disease are terms used to describe the reduced skeletal mineralization seen in preterm babies at term as compared with those who have remained in utero. During the last trimester of pregnancy there is a rapid accretion of calcium and phosphorus due to active transport across the placenta(l). The osteopenia makes the preterm newborn more susc...

Metabolic bone disease is a well recognized problem in premature infants. It has been called "osteopenia, osteoporosis, hypomineralization, undermineralization, demineralization, or rickets of prematurity." As stressed by Brooke and Lucas (1), no term is ideal for a condition that encompasses a variety of disturbances ranging from mild undermineralization to frank radiological rickets with frac...