Objective(s): Here we investigated the regulation of Th17 and Treg cells in orthodontic tooth movement during periodontal inflammation.Materials and Methods: Fifty-six SD rats were divided into a control (24 rats) and a tooth movement group during the recovery stage of periodontitis (RM group, 32 rats). Periodontitis was established by s...

Breast cancer (BC) metastases to bone disrupt the balance between osteoblasts and osteoclasts, leading excessive resorption. We identified a novel subpopulation of with tumor-inhibitory properties, called educated (EOs). Here we sought examine effect EOs on osteoclastogenesis during tumor progression. hypothesized that affect osteoclast development in bone-tumor niche, suppressed pre-osteoclast...

statement of the problem: various researchers have suggested the use of β2-adrenergic receptor antagonists in prevention or treatment of bone resorption. purpose: this study aimed to evaluate the effect of β2-adrenergic receptor antagonists on number of osteoclasts and osteoblasts involved in the healing of extraction socket of maxillary first molar in rats. materials and method: maxillary firs...

ClC-7 Cl(-) channels expressed in osteoclasts are important for bone resorption since it has been shown that disruption of the ClCN7 gene in mice leads to severe osteopetrosis. We have previously reported that Cl(-) currents recorded from mouse osteoclasts resemble those of ClC-3 Cl(-) channels. The aim of the present study was to determine the expression of ClC-3 channels in mouse osteoclasts ...

1. Abstract 2. Introduction 3. Discussion 3.1. Integrins and Osteoclasts 3.1.1. Mechanism of Osteoclastic Bone Resorption 3.1.2. Integrin alphavbeta3 is Involved in Regulating Osteoclastic Bone Resorption 3.2. PYK2 in Osteoclasts 3.2.1. Functional Expression of PYK2 in Osteoclasts 3.2.2. PYK2 in Integrin alphavbeta3-mediated Signaling in Osteoclasts 3.3. FAK in Osteoclasts 3.3.1. Functional Exp...

The localization of vacuolar H(+)-atpASE (V-ATPase) in osteoclasts of rat tibiae was examined immunohistochemically using antibodies to 57 kD and 72 kD subunits of V-ATPase, with confocal laser scanning microscopy and transmission electron microscopy. The two antibodies showed similar immunoreactivities in osteoclasts. We distinguished three patterns of immunoreactivity in osteoclasts: The firs...

objectives : bone remodeling occurs during orthodontic treatment; this process enables tooth movement. many factors can affect bone remodeling at the cellular level, such as nutritional supplements that can affect tooth movement. the present study was designed to evaluate the effect of dietary vitamin c on orthodontic tooth movement in rats.  materials and methods: this study was carried out on...

The intercellular communication between osteoblasts and osteoclasts is crucial to bone homeostasis. Since Rodan and Martin proposed the control of osteoclasts by osteoblasts in the 1980s, many factors have been isolated from osteoblasts and shown to regulate the differentiation and function of osteoclasts. However, the mechanism by which osteoblasts regulate osteoclasts during bone remodelling ...