Biomechanical influences on bone structure play an important role in the longevity of bone around an implant. The quantity and direction of applied force influence the implant and cause deformation of the bone. FEA was used to analyze the changes in the bone on loading the implant with orthodontic force in oblique and vertical directions and orthopedic force. The Mini-implants used in the prese...

There are more than 30,000 orthopedic implant revision surgeries necessary each year in part due to poor implant fixation with juxtaposed bone. A further emphasis on the current problems associated with insufficient bone implant performance is the fact that many patients are receiving hip implants earlier in life, remaining active older, and that the human lifespan is continuously increasing. C...

In the past, synthetic conventional materials have not served as satisfactory implants. As an example, the current average lifetime of an orthopedic implant (such as hip, knee, ankle, etc.) is only 10 to 15 years. Clearly, such conventional materials (or those materials with constituent dimensions greater than 1 micron) have not invoked suitable cellular responses to regenerate enough bone to a...

Despite the potential for growth factor delivery strategies to promote orthopedic implant healing, there is a need for growth factor delivery methods that are controllable and amenable to clinical translation. We have developed a modular bone growth factor, herein termed "modular bone morphogenetic peptide (mBMP)", which was designed to efficiently bind to the surface of orthopedic implants and...

Patients with osteoporosis and joint disabilities represent a constant growing and challenging population to be treated in the musculoskeletal clinical field. Especially in the case of total hip arthroplasty, new solutions should be developed to compensate for the double negative factors, peri-implant osteolysis, and osteoporotic bone loss, affecting the quality of implant outcome. The goal of ...

With the rapid development of orthopedic implant technology, various bone implant surgeries and procedures (such as bone fractures, repairing defects, and hip and knee replacements) are routinely performed. Although these surgeries are usually successful operations for up to 15 years, implant failure due to loosening of the prostheses does occur for active or heavy patients. Other patients rece...

Implant loosening, bone healing failure, implant-associated infections, and large bony defects remain challenges in orthopedic surgery. surface modifications coatings are being developed to promote osteointegration, prevent colonization by bacteria, release bioactive factors. The following mini-review briefly discusses the clinical problem, explains four “osteos”, presents examples of used for ...

The development of better orthopedic implants is incessant. While current implants can function reliably in the human body for a long period of time, there are still a significant number of cases for which the implants can fail prematurely due to poor osseointegration of the implant with native bone. Increasingly, it is recognized that it is extremely important to facilitate the attachment of o...

For many years orthopedic implants were developed for patients with good bone stock. Recently it has become clear that these implants have a decreased performance when implanted in bone with low density, such as in osteoporosis. Reduced performance in osteoporotic bone is not unexpected because of the reduced quality of the peri-implant bone and the reduced bone-implant contact area. Neverthele...