a simple extremely fast and efficient approach for the synthesis of substituted indazole ingood to excellent yield catalyzed by using silica sulfuric acid (ssa) in dmso solvent at roomtemperature. this is solid state reaction have been attracting the synthetic organic chemist asthey provided enhance reaction rates, less environmental pollution, greater selectivity, cleanerproducts and manipulat...

The plant phenolic compounds such as flavonoids, tannins and phenolic acids appeared to be strong antiradical and antioxidant compounds. The number of hydroxy groups and the presence of a 2,3-double bond and orthodiphenolic structure enhance antiradical and antioxidative activity of flavonoids. The glycosylation, blocking the 3-OH group in C-ring, lack of a hydroxy group or the presence of only...

The replacement of oxygenated functionality (hydroxy and alkoxy) with a fluorine atom is commonly used bioisosteric in medicinal chemistry. In this paper, we use molecular matched-pair analysis to better understand the effects on lipophilicity. It seems that reduced log P compound normally dominant determining size difference. We observe presence additional electron-donating groups an aromatic ...

Pseudomonas fluorescens was grown on mineral salts media with phenol, p-hydroxybenzoic acid, p-hydroxy-phenylacetic acid, or p-hydroxy-trans-cinnamic acid as sole carbon and energy source. Each compound was first hydroxylated, ortho to the hydroxyl group on the benzene ring, to give catechol, protocatechuic acid (3,4-dihydroxy-benzoic acid), homoprotocatechuic acid (3,4-dihydroxy-phenylacetic a...

In an attempt to understand the structural characteristics of phenolic compounds that favour the inhibition of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) formation, this study analyzes the role of twenty-five phenolic compounds on the PhIP produced in phenylalanine/creatinine/oxidised lipid reaction mixtures. The results showed that phenols having two hydroxy groups at meta position...

The striking differences observed in the electron-induced (EI) mass fragmentation pathways of two isomeric benzodipyrans are attributable to hydrogen bonding in these molecules. In the "angular" isomer, 6-butyryl-5-hydroxy-2,2,8,8-tetramethyl-3,4,9,10-tetra-hydro-2H,8H-benzo[1,2-b:3,4-b(1)]dipyran (2), H-bonding occurs between the aromatic OH group and the alpha carbonyl moiety contained in the...

Arylamides of 3-hydroxy-2-naphthoic acid are widely used in the production organic azo pigments, as medicines and pesticides.
 Titanium tetrachloride, tetrabutoxytitanium polybutoxytitanates, previously for synthesis most important them., anilide by boiling latter aniline (184 °C), proved to be ineffective catalysts carrying out this reaction ortho-xylene.
 The study reasons inhibitio...

Aromatic cytokinins (ortho-topolin riboside, 6-benzylaminopurine riboside and 6-(2-hydroxy-3-methoxybenzyla mino)purine riboside) were tested for their possible interaction with human liver microsomal cytochromes P450 by absorption difference spectroscopy. All three compounds were shown to bind to the CYP enzymes producing a high to low spin shift of the heme iron yielding a Soret absorption ba...

Eight different zirconium phenoxyimine complexes were synthesized, characterized and tested as catalysts for ethylene polymerization. The phenoxyimine compounds were prepared by condensation of substituted salicylaldehydes with aliphatic and aromatic amines, the substituted salicylaldehydes from ortho substituted phenols and paraformaldehyde. The introduction of iodo substituents was achieved e...

The ortho-hydroxy aryl Schiff base 2-[(E)-(phenylimino)methyl]phenol and its deutero-derivative have been studied by the inelastic incoherent neutron scattering (IINS), infrared (IR) Raman experimental methods, as well Density Functional Theory (DFT) Density-Functional Perturbation (DFPT) simulations. assignments of vibrational modes within 3500–50 cm?1 spectral region made it possible to state...