Background and Aims: Our previous study has demonstrated that essence of Carum copticum reduces contraction activity of ileum in rat. The present study was designed to find out the effects of nonpolar fraction of Carum copticum essence (NFCCE) on mechanical activity of the isolated ileum in rat. Materials and Methods: For evaluation of spasmolythic property of fraction, different doses of the ...

background and aims: our previous study has demonstrated that essence of carum copticum reduces contraction activity of ileum in rat. the present study was designed to find out the effects of nonpolar fraction of carum copticum essence (nfcce) on mechanical activity of the isolated ileum in rat. materials and methods: for evaluation of spasmolythic property of fraction, different doses of the s...

Diabetes mellitus is a lifestyle-related disease that is characterized by inappropriate or diminished insulin secretion. Ex vivo pharmacological studies of hypoglycemic agents are often conducted using perfused pancreatic preparations. Pancreas preparations for organ bath experiments do not require cannulation and are therefore less complex than isolated perfused pancreas preparations. However,...

Several reference compounds such as Cyclosporin A, Tamoxifen, Verapamil, and our compound 1, known as P-gp modulators, have been tested for their P-gp modulating activity in isolated organ bath. Compound 1 showed the best result in organ bath experiment (EC(50)=14.7 microM), Cyclosporin A and Tamoxifen displayed EC(50)=25.2 and 39.4 microM, respectively.

Papillary muscle isolated from adult mouse hearts can be used to study cardiac contractility during different physiological/pathological conditions. The contractile characteristics can be evaluated independently of external influences such as vascular tonus or neurohumoral status. It depicts a scientific approach between single cell measurements with isolated cardiac myocytes and in vivo studie...

OBJECTIVE Radial artery pedicle tissue cooling during harvesting is one of the major causes of vasospasm. We aimed to compare the effects of the pedicle rewarming method, normothermic organ bath, and one of the most preferred topical antispasmodic agents, verapamil-nitroglycerin solution alone or in combination on the blood flow of radial artery. METHODS Consecutively randomized patients (n=8...

Administration of flumequine and oxolinic acid to halibut Hippoglossus hippoglossus by bath resulted in significant tissue levels of both the antibactenals. Bath treatment using 150 mg 1-' of flumequine and 200 mg 1-' of oxolinic acid for 72 h resulted in flunlequine concentrations of 14.2 pg g-' in muscle and 85.4 pg g-' in abdominal organ homogenate and oxolinic acid concentrations of 9.4 pg ...