herpes simplex virus 1 (hsv-1) unspliced 8.3 latency associated transcript (lat), which located in the long repeat sequences, has been shown to contain at least 16 open reading frames (orf: a-p). one of these orf, orf p, maps almost entirely antisense to hsv-1 neurovirulence gene, icp34.5. both orf p and icp34.5 are located in the long repeat and are antisense overlapping genes. therefore, in o...

Herpes simplex virus 1 (HSV-1) unspliced 8.3 latency associated transcript (LAT), which located in the long repeat sequences, has been shown to contain at least 16 open reading frames (ORF: A-P). One of these ORF, ORF P, maps almost entirely antisense to HSV-1 neurovirulence gene, ICP34.5. Both ORF P and ICP34.5 are located in the long repeat and are antisense overlapping genes. Therefore, in O...

A family of L2Ni(ORF)2 (L2: (Cy3PO)2 4, dcpmS 5, dppf 9, bipyMe2 10; RF = C(CF3)3) complexes is synthesized via selective substitution 2 equiv (DME)NaORF from homoleptic [Ni(ORF)4][Na(DME)]2 complex 1, all characterized by 19F and 1H NMR SCXRD analyses as well elemental analyses. These precursors, activated PhF ? Al(ORF)3, were active in ethylene oligomerization with selectivity toward butenes ...

A complication in the analysis of the role of ICP34.5 gene in the herpes simplex virus type-1 (HSV-1) lifecycle is the presence of overlapping antisense gene, open reading frame P (ORF P), which is also deleted in HSV-1 ICP34.5 negative mutants. A HSV-1 wild type strain (17+) ICP34.5/ORF P deletion mutant (1716) is totally avirulent in animal models and impaired in a number of in vitro function...

Orf is a rare viral zoonosis due to Parapoxvirus infection. Transmission humans occurs through contact with infected goats and sheep. It may be complicated by fever, lymphangitis, lymphadenopathy, bacterial infection, erythema multiforme. Only several cases of autoimmune bullous dermatoses have been described. Bullous pemphigoid secondary an orf was found in ten patients. Herein, we report one ...

DURING the spring and early summer of 1955 an unusually large number of cases of orf were seen in patients attending the various skin clinics in Northern Ireland. The condition aroused considerable interest, and it is hoped that these notes may prove helpful to local practitioners. Orf is an infective disease, caused by a filtrable virus of the pox group, affecting commonly sheep and goats. The...

Introduction Orf disease is a viral disease of sheep and goats that can appear in humans too. The usual presentation is in sites that have direct contact. Clinical manifestation of Orf disease may be unusual in burn patients. Case Report In this case report, we described a rare presentation of Orf disease on a burn scar of a ...

herpes simplex virus type-1 (hsv-1) causes a variety of diseases in human. this virus is a neurotropic pathogen of human that establishes latent infection in the sensory ganglia innervating the site of primary infection. a number of genes including icp34.5 control hsv-1 pathogenicity and icp34.5 has been identified as hsv-1 virulence gene. open reading frame p (orf p) is also a hsv-1 gene that ...

aims: infection with parapoxvirus is an occupational hazard of farm workers, abattoir workers, veterinarians, and others with frequent exposure to sheep, cattle, or goats. the aim of this study was to determine the risk working groups in kashan city, iran. patients & methods: this case series study was performed in the private clinic of dr. afzali in kashan region, iran during 2000-13. diagnosi...