نتایج جستجو برای: Oral bioavailability

تعداد نتایج: 266901  

Hossein Heli, Naghmeh Sattarahmady, Negar Azarpira, Razieh Nazari-Vanani,

Due to low cost, ease of administration, and lack need for trained personnel, the oral route is the most convenient and accessible way to design different medicines that could be simply consumed by patients. Regardless of the great benefits of this route, the main challenge in the bioavailability of oral medications is gastrointestinal instability. Nanotechnology is used to improve the solubili...

Journal: :Gut 1982
C J Young T K Daneshmend C J Roberts

The plasma concentrations of ranitidine after oral and intravenous administration have been measured in 10 healthy young adults, nine cirrhotic patients, and eight healthy elderly people. In the first of these bioavailability was 51 +/- 4% and half life 161 +/- 11 minutes after oral and 124 +/- 5 minutes after intravenous administration. In the cirrhotics bioavailability was increased to 70 +/-...

2012
Shiek S. S. J. Ahmed V. Ramakrishnan

BACKGROUND Poor oral bioavailability is an important parameter accounting for the failure of the drug candidates. Approximately, 50% of developing drugs fail because of unfavorable oral bioavailability. In silico prediction of oral bioavailability (%F) based on physiochemical properties are highly needed. Although many computational models have been developed to predict oral bioavailability, th...

2013
Deepu Bakasta M. G. Shambhu

Oral bioavailability of a drug compound is the significant property for potential drug candidates. Measuring this property can be costly and time-consuming. Quantitative structure-property relationships (QSPRs) are used to estimate the percentage of oral bioavailability, and they are an attractive alternative to experimental measurements. A data set of 217 drug and drug-like compounds with meas...

Journal: :Journal of chemical information and modeling 2007
Tingjun Hou Junmei Wang Wei Zhang Xiaojie Xu

A critically evaluated database of human oral bioavailability for 768 chemical compounds is described in this study (http://modem.ucsd.edu/adme), which provides the scientific community a publicly available and reliable source for developing predictive models of human oral bioavailability. The correlations between several important molecular properties and human oral bioavailability were invest...

Journal: :Canadian Medical Association Journal 2019

Journal: :iranian journal of pharmaceutical research 0
yue cao college of pharmaceutical sciences, soochow university li-li shi college of pharmaceutical sciences, soochow university qing-ri cao college of pharmaceutical sciences, soochow university mingshi yang faculty of health and medical sciences, university of copenhagen jing-hao cui college of pharmaceutical sciences, soochow university

poorly water-soluble drugs often suffer from limited or irreproducible clinical response due to their low solubility and dissolution rate. in this study, organic solvent-free solid dispersions (osf-sds) containing telmisartan (tel) were prepared using polyvinylpyrrolidone k30 (pvp k30) and polyethylene glycol 6000 (peg 6000) as hydrophilic polymers, sodium hydroxide (naoh) as an alkalizer, and ...

2016
Shamama Javed Waquar Ahsan Kanchan Kohli

Maximizing oral bioavailability is therapeutically important because the extent of bioavailability directly influences plasma concentrations and therapeutic efficacy after oral drug administration. Bioavailability of poor bioavailable drugs can be increased from the many available approaches in the literature and the most recent approach is the use of bioavailability enhancers. The use of bioen...

1998
JOHN T. MCCLOSKEY IRVIN R. SCHULTZ MICHAEL C. NEWMAN

In classical pharmacology, oral bioavailability of a toxicant is defined as that fraction of an orally administered dose reaching the systemic circulation of the animal. The present study estimates the bioavailability of methylmercury in channel catfish (Ictalurus punctatus) by comparing concentrations in the blood through time after oral and intra-arterial (IA) administration. Catfish were can...

2012
Ayman El-Kattan

Most of the drugs that are available in the marketplace are administered via the oral route, which is a convenient and cost effective route of administration (Lipinski 1995; Lipinski 2000; Lipinski et al. 2001; Lipinski 2004; Abrahamsson and Lennernas 2005). Thus, oral bioavailability is one of the key considerations for discovery and development of a new chemical entity (NCE). It is well recog...

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