experimental autoimmune vitiligo was induced by the intradermal injection of the purified mushroom tyrosinase emulsified in complete freund’s adjuvant (cfa) in female c57bl/6 mice. the onset of vitiligo was characterized by hair hypopigmentation and total melanocyte depletion in the basal layer of the epidermis. oral administration of semipurified mushroom tyrosinase prevented experimental auto...

objective: most   neonates admitted to neonatal wards do not tolerate sufficient milk.  recently the effect of erythromycin on increasing feeding tolerance in neonates has been studied. in this study the effectiveness of oral, high dose erythromycin a prokinetic agent was used to enhance feeding tolerance in these neonates.  methods: this prospective randomized controlled clinical trial was con...

Oral tolerance is a physiological immune mechanism, which controls the outcome of deleterious hypersensitivity reactions to environmental antigens absorbed through the gastrointestinal tract, and maintains homeostasis. Using a mouse model of oral tolerance of delayed type hypersensitivity to contact allergens, i.e. haptens, we have examined the mechanisms involved in the induction of oral toler...

background: autoimmune type 1 diabetes mellitus is caused by t-cell mediated immune destruction of the insulin-producing β-cell in pancreatic islets of langerhans. specificity of the auto-antibodies and of the auto-reactive t-cells has been investigated, in which several auto-antigens were proposed. objective: to determine whether glutamic acid decarboxylase (gad) feeding would induce oral tole...

allergy to wheat is a common food allergy. in spite of this fact, there is not enough literature regarding the features and outgrowing of this allergy. the objective of this study was to evaluate the manifestations of this allergy and to follow the patients to evaluate whether outgrowing allergy happens again and when it occurs. eight wheat allergic patients diagnosed between 2000 and 2001 were...

background: gestational diabetes mellitus (gdm) is the most common metabolic complications of pregnancy and causes fetal mortality and morbidity. therefore early diagnosis of gdm is necessary to reduce maternal and fetal morbidity and to help prevent or delay the onset of type 2 diabetes objective: this prospective study was carried out to determine the incidence of gdm in yazd and to assess th...

cow’s milk allergy (cma) is the most frequent food allergy in children and oral immunotherapy (oit) is a promising approach for treatment of patients. the most challenging cases are anaphylactic with coexisting asthma and proposing safe protocols is crucial especially in high risk groups. considering that cma varies among patients, an individualized oit protocol would be beneficial to achieve a...