OBJECTIVES To report the clinical features and outcome of 24 Brazilian patients with optic neuromyelitis syndrome (ONM); discuss the underlying pathological events associated with the ONM syndrome; review the nosological situation of ONM in the group of inflammatory and demyelinating diseases of the central nervous system. PATIENTS AND METHODS Patients with ONM treated at the Hospital da Lago...

Oncostatin M (OnM) signals through cell surface receptors, which utilize the gp130 subunit. In cultured human umbilical vein endothelial cells (HUVEC), OnM transiently elevates mRNA encoding for suppressor of cytokine signaling-3 (SOCS-3). By 1 h of OnM treatment, HUVEC become refractory to the restimulation by OnM, measured as failure to reinduce SOCS-3 mRNA. OnMinduced desensitization also pr...

BACKGROUND We hypothesized that the total face mask (TFM) would be perceived as more comfortable than a standard oronasal mask (ONM) by patients receiving noninvasive mechanical ventilation (NIV) therapy for acute respiratory failure (ARF) and would be quicker to apply by respiratory therapists. METHODS Sixty patients presenting with ARF were randomized to receive NIV via either an ONM or a T...

Observations stretching back more than two decades have suggested that nuclei and nuclear components are mechanically coupled to the cytoskeleton. In multicellular organisms, this mechanical coupling may extend beyond the plasma membrane to the extracellular matrix and adjacent cells. More recently, studies on a variety of human diseases associated with defects in nuclear envelope (NE) proteins...

We appreciate the interest of Dr Barbarito and colleagues in our recent study 1 comparing the total face mask (TFM) with oronasal mask (ONM) for the treatment of acute respiratory failure in patients receiving noninvasive ventilation (NIV). Our primary (mask comfort and time to apply) and secondary (vital signs and gas exchange parameters over time) end points showed no differences. In the inte...

and Applied Analysis 3 in the normal bundle T⊥M, and AN is the shape operator of the second fundamental form. Moreover, we have g ANX, Y g h X,Y ,N , 2.4 where g denotes the Riemannian metric onM as well as the metric induced onM. The mean curvature vector H on M is given by

Our studies on homeostatic restitution of cellular and subcellular membranes showed that vesicular intracellular transport is engaged in systematic and coordinated replacement of lipids and proteins in the membranes of the secretory, non-dividing epithelial cells (Slomiany et al., J. Physiol. Pharmacol. 2004; 55: 837-860). In this report, we present evidence on the homeostatic restitution of li...

We appreciate the interest of Dr Barbarito and colleagues in our recent study 1 comparing the total face mask (TFM) with oronasal mask (ONM) for the treatment of acute respiratory failure in patients receiving noninvasive ventilation (NIV). Our primary (mask comfort and time to apply) and secondary (vital signs and gas exchange parameters over time) end points showed no differences. In the inte...