نتایج جستجو برای: OXA-48

تعداد نتایج: 144813  

2012
Zhiyong Zong

INTRODUCTION bla(OXA-48) is a globally emerging carbapenemase-encoding gene. The progenitor of bla(OXA-48) appears to be a Shewanella species. The presence of the bla(OXA-48)-like gene was investigated for two Shewanella xiamenensis strains. METHODS Strain WCJ25 was recovered from post-surgical abdominal drainages, while S4 was the type strain of S. xiamenensis. Species identification for WCJ...

Journal: :The Journal of antimicrobial chemotherapy 2015
Saoussen Oueslati Patrice Nordmann Laurent Poirel

OBJECTIVES Carbapenem-hydrolysing class D β-lactamases of the OXA-48 type are increasingly reported from Enterobacteriaceae. β-Lactamase OXA-48 hydrolyses penicillins very efficiently, but carbapenems only weakly and spares broad-spectrum cephalosporins. Recently, diverse OXA-48-like β-lactamases have been identified worldwide (OXA-162, OXA-181, OXA-163, OXA-204 and OXA-232). They differ by few...

Journal: :Diagnostic microbiology and infectious disease 2013
Delphine Girlich Claire Anglade Gilles Zambardi Patrice Nordmann

Comparative evaluation of the recently developed chromogenic culture medium chromID OXA-48 (bioMérieux) with chromID CARBA (bioMérieux) and SUPERCARBA showed that chromID OXA-48 and SUPERCARBA media have the highest sensitivity for detection of OXA-48 producing Enterobacteriaceae (91% and 93%) comparatively to chromID CARBA (21 %). The chromID OXA-48 has the highest specificity, with 100%, as c...

Journal: :Antimicrobial agents and chemotherapy 2014
R Beyrouthy F Robin J Delmas L Gibold G Dalmasso F Dabboussi M Hamzé R Bonnet

The OXA-48 carbapenemase is mainly encoded by ∼ 62-kb IncL/M plasmids. However, chromosome-mediated genes have been observed in Escherichia coli isolates. In this work, we investigated the genetic environment of OXA-48 in members of the family Enterobacteriaceae (n = 22) to understand how the OXA-48-encoding gene is transferred into the E. coli chromosome. The OXA-48-encoding gene was located w...

2014
Fabrice Compain Dominique Decré Isabelle Frazier Astrid Ramahefasolo Marie Lavollay Etienne Carbonnelle Hidayeth Rostane Arzu Tackin Anne Berger-Carbonne Isabelle Podglajen

Technical Appendix Table. β-lactamase profiles of multidrug-resistant Gram-negative bacilli isolated in 2010 and 2011, France* Region of origin No. culture-positive patients/total no. patients Species No. isolates β-lactamase ESBL Carbapenemase pCASE Africa 33/87 E. coli 18 CTX-M-15 2 CTX-M-1 2 SHV-12 1 CTX-M-3 OXA-48 1 CTX-M-14 1 CTX-M-15 TEM-169 1 CTX-M-15 CMY-2 1 CTX-M-24 OXA-48 1 ND K. pneu...

Journal: :Antimicrobial agents and chemotherapy 2015
Liang Chen Nahed Al Laham Kalyan D Chavda Jose R Mediavilla Michael R Jacobs Robert A Bonomo Barry N Kreiswirth

We report the first multidrug-resistant Proteus mirabilis strain producing the carbapenemase OXA-48 (Pm-OXA-48) isolated at Al-Shifa hospital in Gaza, Palestine. Draft genome sequencing of Pm-OXA-48 identified 16 antimicrobial resistance genes, encoding resistance to β-lactams, aminoglycosides, fluoroquinolones, phenicols, streptothricin, tetracycline, and trimethoprim-sulfamethoxazole. Complet...

Journal: :The Journal of antimicrobial chemotherapy 2016
Danièle Meunier Anna Vickers Rachel Pike Robert L Hill Neil Woodford Katie L Hopkins

Sir, The worldwide emergence of carbapenemases is a major health issue leaving clinicians with few treatment options. Implementation of infection prevention and control (IPC) procedures relies on early detection of carbapenemase producers and distinction from other carbapenem resistance mechanisms. Various carbapenem hydrolysis methods allow detection of carbapenemase activity but do not differ...

Journal: :The Journal of antimicrobial chemotherapy 2012
Laurent Poirel Anaïs Potron Patrice Nordmann

OXA-48-type carbapenem-hydrolysing class D β-lactamases are increasingly reported in enterobacterial species. To date, six OXA-48-like variants have been identified, with OXA-48 being the most widespread. They differ by a few amino acid substitutions or deletions (one to five amino acids). The enzymes hydrolyse penicillins at a high level and carbapenems at a low level, sparing broad-spectrum c...

Journal: :Journal of clinical and diagnostic research : JCDR 2013
M Shanthi Uma Sekar Arunagiri K Hemant Goverdhandas Bramhne

BACKGROUND Detection of carbapenem hydrolyzing class D beta lactamase OXA-181, (a variant of OXA-48) in Enterobacteriaceae, is important, to institute appropriate therapy and to initiate preventive measures. This study was done to determine the presence of OXA 48 and its derivative OXA-181 in Enterobacteriaceae of pathogenic significance. MATERIAL AND METHODS One hundred and eleven non-repeti...

Journal: :Antimicrobial Agents and Chemotherapy 2021

OXA-48-type ?-lactamases are now routinely encountered in bacterial infections caused by carbapenem-resistant Enterobacterales . These enzymes of high and growing clinical significance due to the importance carbapenems treatment health care-associated Gram-negative bacteria, wide increasing dissemination OXA-48 on plasmids, challenges posed their detection.

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