oxidized ldl (ox-ldl) lipoproteins are proposed as important modified particles triggering pro-inflammatory events through receptor-mediated pathways. we evaluated the circulating ox-ldl level on the concept that the chronic immune events may affect ox-ldl clearance as the vessel stenosis develops in coronary arteries. one hundred sixty five subjects underwent coronary angiography and then, sub...

different classes of autoantibodies against two antigenic forms of modified low density lipoprotein (mod-ldl) were detected in 140 patients by indirect elisa method. investigated autoantibodes included total immunoglobulins (igt). immunoglobulin g (igg), and immunoglobulin m (igm) against oxidized ldl with copper ions (ox-ldl) and modified ldl with malondialdehyde (mal-ldl) (igt-o) igt against ...

OBJECTIVE The purpose of the present study was to investigate the value of ox-LDL and oxidation ratio of LDL (ox-LDL/TC, ox-LDL/HDL-C and ox-LDL/LDL-C) in diagnosis and prognosis evaluation in CAD patients. Also, we aimed to observe the effect of statins on reducing level of ox-LDL and oxidation ratio of LDL, and explore whether statins still have similar effect on ox-LDL in a short period of t...

OBJECTIVE Oxidized LDL cholesterol (ox-LDL-C) is considered to be a key factor of initiating and accelerating atherosclerosis (AS). The purpose of this study is to elucidate the sensitivity and specificity of ox-LDL and oxidation ratio of LDL in the diagnosis of coronary artery disease (CAD). For the first time, we investigated the ratio of ox-LDL to ALB(ox-LDL/ALB). METHODS AND RESULTS Blood...

Objective: To assess the oxidized low density lipoprotein (ox-LDL) to (LDL) ratio as an indicator of subclinical atherosclerosis in haemodialysis patients Methodology: This case control study was carried out at Jinnah Post Graduate Medical Center Karachi, from January December 2018. The were selected dialysis center (group B) whereas controls recruited normal healthy population A). access statu...

Endothelial dysfunction, or activation, elicited by oxidized low density lipoprotein (Ox-LDL) and its lipid constituents has been shown to play a key role in the pathogenesis of atherosclerosis. We recently have identified a novel receptor for Ox-LDL-designated lectin-like Ox-LDL receptor (LOX-1) in vascular endothelial cells. To examine ligand specificity of LOX-1, we established CHO cell line...

Introduction Astaxanthin (ASX) is carotenoid with the highest antioxidant activity in various cell types and reverse atherosclerosis. However, roles detailed mechanisms of ASX atherosclerosis associated endothelial injury remains unclear. Methods In vitro model was established HUVECs by incubation oxidized low-density lipoprotein (ox-LDL). Cell viability oxidative stress were measured. The mRNA...

The rate of degradation of oxidatively modified low density lipoprotein (Ox-LDL) by human endothelial cells was similar to that of unmodified low density lipoprotein (LDL), and was approximately 2-fold greater than the rate of degradation of acetylated LDL (Ac-LDL). While LDL and Ac-LDL both stimulated cholesterol esterification in endothelial cells, Ox-LDL inhibited cholesterol esterification ...

OBJECTIVE Circulating oxidized LDL (Ox-LDL) is associated with clinical manifestations of atherosclerosis. However, no previous study has examined the relationship between subclinical atherosclerosis and Ox-LDL. The aims of the present study were to investigate the relationship between clinically silent ultrasound-assessed atherosclerotic changes in the carotid and femoral arteries and Ox-LDL a...