نتایج جستجو برای: OLR1

تعداد نتایج: 129  

2011
Magomed Khaidakov Sona Mitra Bum-Yong Kang Xianwei Wang Susan Kadlubar Giuseppe Novelli Vinay Raj Maria Winters Weleetka C. Carter Jawahar L. Mehta

Recent studies have linked expression of lectin-like ox-LDL receptor 1 (OLR1) to tumorigenesis. We analyzed microarray data from Olr1 knockout (KO) and wild type (WT) mice for genes involved in cellular transformation and evaluated effects of OLR1 over-expression in normal mammary epithelial cells (MCF10A) and breast cancer cells (HCC1143) in terms of gene expression, migration, adhesion and tr...

Journal: :Journal of cellular and molecular medicine 2016
Elena Morini Barbara Rizzacasa Sabina Pucci Chiara Polidoro Fabrizio Ferrè Daniela Caporossi Manuela Helmer Citterich Giuseppe Novelli Francesca Amati

The up-regulation of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), encoded by the OLR1 gene, plays a fundamental role in the pathogenesis of atherosclerosis. Moreover, OLR1 polymorphisms were associated with increased susceptibility to acute myocardial infarction (AMI) and coronary artery diseases (CAD). In these pathologies, the identification of therapeutic approaches that ...

Journal: :Journal of medical genetics 2003
R Mango F Clementi P Borgiani G B Forleo M Federici G Contino E Giardina L Garza I E Fahdi R Lauro J L Mehta G Novelli F Romeo

A cute myocardial infarction (AMI) is a significant cause of mortality and morbidity. Substantial data support a plausible role for oxidised LDL (oxLDL) in the aetiology of this disease. 2 The human OLR1 (or LOX 1) gene encodes the endothelium derived lectin-like oxidised low density lipoprotein (oxLDL) receptor, which is involved in the binding, internalisation, and proteolytic degradation of ...

2017
Barbara Rizzacasa Elena Morini Sabina Pucci Michela Murdocca Giuseppe Novelli Francesca Amati

Alternative splicing (AS) is a process in which precursor messenger RNA (pre-mRNA) splicing sites are differentially selected to diversify the protein isoform population. Changes in AS patterns have an essential role in normal development, differentiation and response to physiological stimuli. It is documented that AS can generate both "risk" and "protective" splice variants that can contribute...

2003
R Mango F Clementi P Borgiani G B Forleo M Federici G Contino E Giardina L Garza I E Fahdi R Lauro J L Mehta G Novelli F Romeo

A cute myocardial infarction (AMI) is a significant cause of mortality and morbidity. Substantial data support a plausible role for oxidised LDL (oxLDL) in the aetiology of this disease. 2 The human OLR1 (or LOX 1) gene encodes the endothelium derived lectin-like oxidised low density lipoprotein (oxLDL) receptor, which is involved in the binding, internalisation, and proteolytic degradation of ...

2005
Patricia C. Chui Hong-Ping Guan Michael Lehrke Mitchell A. Lazar

In addition to its role in energy storage, adipose tissue also accumulates cholesterol. Concentrations of cholesterol and triglycerides are strongly correlated in the adipocyte, but little is known about mechanisms regulating cholesterol metabolism in fat cells. Here we report that antidiabetic thiazolidinediones (TZDs) and other ligands for the nuclear receptor PPARγ dramatically upregulate ox...

Journal: :RNA 2015
J Ramón Tejedor Hagen Tilgner Camilla Iannone Roderic Guigó Juan Valcárcel

The OLR1 gene encodes the oxidized low-density lipoprotein receptor (LOX-1), which is responsible for the cellular uptake of oxidized LDL (Ox-LDL), foam cell formation in atheroma plaques and atherosclerotic plaque rupture. Alternative splicing (AS) of OLR1 exon 5 generates two protein isoforms with antagonistic functions in Ox-LDL uptake. Previous work identified six single nucleotide polymorp...

The present study was carried out to investigate the association of C/T single nucleotide polymorphism(SNP)in exon 5 of stearoyl-CoA desaturase 1 (SCD1) gene and A/C SNP in the 3' untranslated region of oxidized low density lipoprotein receptor 1 (OLR1)gene with milk production traits in Iranian Holstein dairy Cattle. The blood samples of 153 (for OLR1) and 308 (for SCD1) dairy cattle from thre...

Journal: :Circulation research 2005
Ruggiero Mango Silvia Biocca Francesca del Vecchio Fabrizio Clementi Federica Sangiuolo Francesca Amati Antonio Filareto Sandro Grelli Paola Spitalieri Ilaria Filesi Cartesio Favalli Renato Lauro Jawahar L Mehta Francesco Romeo Giuseppe Novelli

Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), encoded by the OLR1 gene, is a scavenger receptor that plays a fundamental role in the pathogenesis of atherosclerosis. LOX-1 activation is associated with apoptosis of endothelial cells, smooth muscle cells (SMCs), and macrophages. This process is an important underlying mechanism that contributes to plaque instability and subseq...

2012
Rajneesh TRIPATHI Satyendra TEWARI Sarita AGARWAL

The human lectin-like oxidized low-density lipoprotein receptor 1 (OLR1/LOX-1) is expressed on the endothelial cells, macrophages, and vascular smooth muscle cells. It internalizes Ox-LDL leading to multiple effects on endothelial dysfunctions and atherosclerosis (Knowles et al., 2008). The expression of OLR1 gene has been observed in vivo (placenta, lungs, brain, and liver) and in vitro (aorti...

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