نتایج جستجو برای: ODC1

تعداد نتایج: 48  

Journal: :American journal of physiology. Endocrinology and metabolism 2011
Nicole K L Lee Jarrod P J Skinner Jeffrey D Zajac Helen E MacLean

The aim of this study is to determine if the Odc1 gene, which encodes ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis, is directly regulated by the androgen receptor (AR) in skeletal muscle myoblasts and if Odc1 regulates myoblast proliferation and differentiation. We previously showed that expression of Odc1 is decreased in muscle from AR knockout male mice. I...

Journal: :Molecular pharmacology 2016
Chakravarthi Chintalapati Thorsten Keller Thomas D Mueller Valentin Gorboulev Nadine Schäfer Ilona Zilkowski Maike Veyhl-Wichmann Dietmar Geiger Jürgen Groll Hermann Koepsell

Na+-d-glucose cotransporter 1 (SGLT1) is rate-limiting for glucose absorption in the small intestine. Shortly after intake of glucose-rich food, SGLT1 abundance in the luminal membrane of the small intestine is increased. This upregulation occurs via glucose-induced acceleration of the release of SGLT1-containing vesicles from the trans-Golgi network (TGN), which is regulated by a domain of pro...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2009
Jason A Zell Argyrios Ziogas Natalia Ignatenko Jane Honda Ning Qu Alexander S Bobbs Susan L Neuhausen Eugene W Gerner Hoda Anton-Culver

PURPOSE Activity of ornithine decarboxylase (ODC), the first enzyme in polyamine synthesis, is required for normal growth and is elevated in many cancers, including colorectal cancer. We examined associations of the +316 ODC1 single nucleotide polymorphism (SNP) with colorectal cancer-specific survival among colorectal cancer cases, and then investigated its functional significance in colon can...

Journal: :Microbiological research 2011
Jaime Madrigal Pulido Israel Padilla Guerrero Isaura de J Magaña Martínez Briseida Cacho Valadez Juan Carlos Torres Guzman Eduardo Salazar Solis J Felix Gutierrez Corona Augusto Schrank Francisco Jiménez Bremont Angélica González Hernandez

The gene ODC1, which codes for the ornithine decarboxylase enzyme, was isolated from the entomopathogenic fungus, Metarhizium anisopliae. The deduced amino acid sequence predicted a protein of 447 amino acids with a molecular weight of 49.3 kDa that contained the canonical motifs of ornithine decarboxylases. The ODC1 cDNA sequence was expressed in Escherichia coli cells; radiometric enzyme assa...

Journal: :Journal of the National Cancer Institute 2010
Jason A Zell Christine E McLaren Wen-Pin Chen Patricia A Thompson Eugene W Gerner Frank L Meyskens

The ornithine decarboxylase-1 (ODC1) polymorphism at position +316 affects binding by transcriptional activators and repressors and modulates the risk of metachronous colorectal adenomas, particularly in association with aspirin use. We investigated the effects of ODC1 after treatment with difluoromethylornithine (eflornithine)/sulindac or placebo. Two hundred twenty-eight colorectal adenoma pa...

Journal: :The Journal of biological chemistry 1998
G L Law H Itoh D J Law G J Mize J L Merchant D R Morris

Appropriate cellular levels of polyamines are required for cell growth and differentiation. Ornithine decarboxylase is a key regulatory enzyme in the biosynthesis of polyamines, and precise regulation of the expression of this enzyme is required, according to cellular growth state. A variety of mitogens increase the level of ornithine decarboxylase activity, and, in most cases, this elevation i...

Journal: :Cancer research 2008
Michael D Hogarty Murray D Norris Kimberly Davis Xueyuan Liu Nicholas F Evageliou Candace S Hayes Bruce Pawel Rong Guo Huaqing Zhao Eric Sekyere Joanna Keating Wayne Thomas Ngan Ching Cheng Jayne Murray Janice Smith Rosemary Sutton Nicola Venn Wendy B London Allen Buxton Susan K Gilmour Glenn M Marshall Michelle Haber

Neuroblastoma is a frequently lethal childhood tumor in which MYC gene deregulation, commonly as MYCN amplification, portends poor outcome. Identifying the requisite biopathways downstream of MYC may provide therapeutic opportunities. We used transcriptome analyses to show that MYCN-amplified neuroblastomas have coordinately deregulated myriad polyamine enzymes (including ODC1, SRM, SMS, AMD1, ...

2017
Xijing He Liying Fan Zhongheng Wu Jiaxuan He Bin Cheng

Previous gene expression profiling studies of neuropathic pain (NP) following spinal cord injury (SCI) have predominantly been performed in animal models. The present study aimed to investigate gene alterations in patients with spinal cord injury and to further examine the mechanisms underlying NP following SCI. The GSE69901 gene expression profile was downloaded from the public Gene Expression...

Journal: :The Journal of biological chemistry 2005
Christine Schwimmer Linnka Lefebvre-Legendre Malgorzata Rak Anne Devin Piotr P Slonimski Jean-Paul di Rago Michel Rigoulet

In a previous study we have identified Fmc1p, a mitochondrial protein involved in the assembly/stability of the yeast F0F1-ATP synthase at elevated temperatures. The deltafmc1 mutant was shown to exhibit a severe phenotype of very slow growth on respiratory substrates at 37 degrees C. We have isolated ODC1 as a multicopy suppressor of the fmc1 deletion restoring a good respiratory growth. Odc1p...

2009
Jason A. Zell Argyrios Ziogas Natalia Ignatenko Jane Honda Ning Qu Alexander S. Bobbs Susan L. Neuhausen Eugene W. Gerner Hoda Anton-Culver

Purpose: Activity of ornithine decarboxylase (ODC), the first enzyme in polyamine synthesis, is required for normal growth and is elevated in many cancers, including colorectal cancer. We examined associations of the +316 ODC1 single nucleotide polymorphism (SNP) with colorectal cancer–specific survival among colorectal cancer cases, and then investigated its functional significance in colon ca...

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