Rhubarb is commonly used to treat constipation in China and anthraquinones (AQs) are the active components present in rhubarb. However, an increasing number of studies have reported that AQs induce nephrotoxicity. In the present study, rhubarb total free anthraquinones (RTFA) oral colon-specific drug delivery granules (RTFA-OCDD-GN) were prepared to determine whether RTFA-OCDD-GN could reduce t...

via a photolytic condensation reaction. After exposing small pieces of penta-treated wood for 20 days to natural and artificial light, measured OCDD concentrations of about 70 ppm (ng OCDD/mg PCP). The OCDD in turn degraded to HpCDD and HxCDD (heptaand hexa-chlorodibenzodioxin). The final concentration of HxCDD was approximately 15 20 ppm. When P-9 oil was used as the solvent for penta, concent...

Intestinal absorption mechanisms of young calves change rapidly during the first 24 h postpartum and subsequently effect the absorption efficiencies of a wide range of compounds. This study was conducted to determine absorption efficiencies of (p,p'-dichlorodiphenyl)dichloroethylene (DDE), 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153), and 1,2,3,4,6,7,8,9-octachlorodibenzo-p-dioxin (OCDD) when ad...

OBJECTIVE To study neuropsychological function in subjects with obsessive-compulsive disorder (OCD) with and without co-morbid depression in comparison with healthy controls (HC). METHODS The 3 sample groups included subjects with OCD without depression (OCD group, n = 30); subjects with OCD and depression (OCDD group, n = 20); and HC (n = 25). All 3 groups were matched for age, gender, and y...

BACKGROUND Once ingested, dioxins and dioxin-like compounds are excreted extremely slowly. Excretion can be evaluated by its half-life. Half-lives estimated from observed concentrations are affected by excretion and ongoing exposure. We investigated the change in apparent half-life using a theoretical model based on exposure to dioxin and dioxin-like compounds. METHODS We carried out longitud...

Background: Once ingested, dioxins and dioxin-like compounds are excreted extremely slowly. Excretion can be evaluated by its half-life. Half-lives estimated from observed concentrations are affected by excretion and ongoing exposure. We investigated the change in apparent half-life using a theoretical model based on exposure to dioxin and dioxin-like compounds. Methods: We carried out longitud...

In the present study, we aimed to prepare rhubarb total anthraquinones oral colon-specific drug delivery granules (RTA-OCDDGN) for delivering rhubarb free anthraquinones to colon. RTA-OCDD-GN was successfully prepared through a double-layer coating process using chitosan as an inner layer and Eudragit S100 as an outer enteric coating layer. The pharmacodynamics and toxicological results showed ...

quantum chemical calculations, based on density functional theory (dft) method, were performed on calix[4]arene and polychlorinated dibenzo-p-dioxins (pcdds) in gas and liquid phases for comparison purposes. the simulation results show the 1,2,3,4, 6,7,8,9-octachlorodibenzo-p-dioxin (ocdd) is quite a reactive dioxin. this paper attempts to examine the possibility of dioxin adsorption by calix[n...

Quantum chemical calculations, based on Density Functional Theory (DFT) method, were performed on Calix[4]arene and Polychlorinated Dibenzo-p-dioxins (PCDDs) in gas and liquid phases for comparison purposes. The simulation results show the 1,2,3,4, 6,7,8,9-octachlorodibenzo-p-dioxin (OCDD) is quite a reactive dioxin. This paper attempts to examine the possibility of dioxin adsorption by Calix[n...

Between 1999 and 2020, there were twelve rapid alerts on dioxins in palm fatty acid distillate (PFAD) products, six of which associated with hydrogenated distillates (HPFADs). In oil refineries for food feed, refined PFADs can be processed into HPFADs. This study investigated the effect hydrogenation products contain OCDD impact profiles toxic equivalent (TEQ) level. Palm spiked octachlorodiben...