We present here the synthesis of a highly O-carboxymethylated chitosan derivative. First, an improvedprotocol for the two-step synthesis of N-trimethyl chitosan (TMC) from chitosan was developed, yield-ing a maximum degree of quaternization (DQ) of up to 46.6%. Successively, the chitosan derivativeO-carboxymethyl-N-trimethyl chitosan (CMTMC) was synthesized from the TMC obtained by applyingan o...

Chitosan and its derivatives have attracted great attention due to their properties beneficial for application to wound healing. The main focus of the present review is to summarize studies involving chitosan and its derivatives, especially N,N,N-trimethyl-chitosan (TMC), N,O-carboxymethyl-chitosan (CMC) and O-carboxymethyl-N,N,N-trimethyl-chitosan (CMTMC), used to accelerate wound healing. Mor...

Background: Shigella flexneri is a pathogen responsible for shigellosis around the world, especially in developing countries. Many immunogenic antigens have been introduced as candidate vaccines against Shigella, including N-terminal region of IpaD antigen (NIpaD). Objective: To evaluate the efficiency of O-metylated free trimethyl chitosan na...

Objective(s): The purpose of this study is about the preparation and evaluation of nanoparticles composed of thiolated methylated pyridinyl chitosan (TMPC) which are made P.E.C method, for bucal drug delivery of insulin.Materials and Methods: First of all have to synthesize methylated pyridinyl chitosan and then for (TMPC) L-cysteine should be attached to methylated pyridinyl chitosan by the fo...

A series of water-soluble cationic chitosan derivatives were prepared by chemoselective functionalization at the amino group of five different parent chitosans having varying degrees of acetylation and molecular weight. The quaternary moieties were introduced at different alkyl spacer lengths from the polymer backbone (C-0, C-2 and C-6) with the aid of 3,6-di-O-tert-butyldimethylsilyl protectio...

objective(s): the purpose of this study is about the preparation and evaluation of nanoparticles composed of thiolated methylated pyridinyl chitosan (tmpc) which are made p.e.c method, for bucal drug delivery of insulin.materials and methods: first of all have to synthesize methylated pyridinyl chitosan and then for (tmpc) l-cysteine should be attached to methylated pyridinyl chitosan by the fo...

background: influenza outbreak has become a great lifethreateningdisease in the world. nasal vaccines can inducesystemic igg and mucosal iga antibody responses, whichestablish two layers of immune defense against the infectiouspathogens like influenza. mucosal vaccines must overcomeseveral limitations, including the mucociliary clearance andinefficient uptake of soluble antigens. therefore, nas...

BACKGROUND Camptothecin (CPT) has recently attracted increasing attention as a promising anticancer agent for a variety of tumors. But the clinical application is largely hampered by its extreme water insolubility and unpredictable side effect. It is essential to establish an efficient and safe protocol for the administration of CPT versus melanoma. METHODS Camptothecin was encapsulated with ...