hyperleukocytosis is an oncological emergency but is extremely rare in non-malignant conditions. nucleated rbcs give rise to spuriously high total leucocyte count and cause clinical dilemma. thalassemia major patients are known to have leucocytosis even after correction for nucleated rbcs. we report a case of undiagnosed thalassemia major in a 4 month old infant with total leucocyte count highe...

Hyperleukocytosis is an oncological emergency but is extremely rare in non-malignant conditions. Nucleated RBCs give rise to spuriously high total leucocyte count and cause clinical dilemma. Thalassemia major patients are known to have leucocytosis even after correction for nucleated RBCs. We report a case of undiagnosed Thalassemia major in a 4 month old infant with total leucocyte count highe...

The cell in Image BCI-01 is a nucleated red blood cell (RBC). Although nucleated RBCs do not normally appear in the peripheral blood of an adult, it is not unexpected in this patient’s condition owing to hematopoietic bone marrow stress. Nucleated RBCs are immature erythrocytes that still retain their nucleus. The cell in this image is typical of those most often seen in the peripheral blood of...

Manual hemacytometer cell counting of body fluids is labor-intensive and requires skilled testing personnel. We performed a multicenter evaluation of the Iris iQ200 automated microscopy analyzer Body Fluids Module (Iris Diagnostics, Chatsworth, CA) and compared 350 iQ200 body fluid cell counts with manual hemacytometer cell counts. Within-run imprecision, expressed as coefficient of variation (...

With the exception of mammals, vertebrate erythrocytes are nucleated. Nevertheless, these cells are usually considered as mere carriers of hemoglobin. In this work, however, we describe for the first time an unrecognized role of teleost red blood cells (RBCs). We found that Nk-lysin (Nkl), an antimicrobial peptide produced by NK-cells and cytotoxic T-lymphocytes, was also expressed in flatfish ...

Background: Early diagnosis of perinatal asphyxia is very essential since it is a major cause of neurologic morbidity and mortality. The present study was undertaken to investigate the association between nucleated red blood cells count (RBCs) per 100 white blood cells (WBCs) and perinatal asphyxia with respect to its severity and prognosis. Materials and Methods: A prospective case-control stu...

Reported findings of elevated total calcium (Ca) contents in erythrocytes (RBCs) from patients with $-thalassemia intermedia (fl-TI) prompted the question of whether the state and transport of Ca in these RBCs are similar to those in sickle cell anemia (SS) RBCs where the increased Ca is compartmentalized in endocytic inside-out vesicles and extracted by exposure of the cells to the Ca ionophor...

Reported findings of elevated total calcium (Ca) contents in erythrocytes (RBCs) from patients with $-thalassemia intermedia (fl-TI) prompted the question of whether the state and transport of Ca in these RBCs are similar to those in sickle cell anemia (SS) RBCs where the increased Ca is compartmentalized in endocytic inside-out vesicles and extracted by exposure of the cells to the Ca ionophor...