نتایج جستجو برای: Non-viral carrier

تعداد نتایج: 1513344  

Journal: :nanomedicine journal 0
hamideh parhiz pharmaceutical research center, school of pharmacy, mashhad university of medical sciences, mashhad, iran department of pharmaceutical biotechnology, school of pharmacy, mashhad university of medical sciences, mashhad, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (mashhad university of medical sciences) maryam hashemi nanotechnology research center, school of pharmacy, mashhad university of medical sciences, mashhad, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (mashhad university of medical sciences) mohammad ramezani pharmaceutical research center, school of pharmacy, mashhad university of medical sciences, mashhad, iran department of pharmaceutical biotechnology, school of pharmacy, mashhad university of medical sciences, mashhad, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (mashhad university of medical sciences)

gene therapy as a modern therapeutic approach has not yet advanced to a globally-approved therapeutic approach. lack of adequate reliable gene delivery system seems to be one of the major reasons from the pharmaceutical biotechnology point of view. main obstacles delaying successful application of human gene therapy are presented in this review. the unique advantages of non-biological gene carr...

2015
Aravindh Babu R. Parthiban Mana Mahapatra Simon Gubbins Satya Parida Jagadeesh Bayry

The role of foot-and-mouth disease virus (FMDV) carrier cattle in causing new outbreaks is still a matter of debate and it is important to find out these carrier animals by post-outbreak serosurveillance to declare freedom from FMDV infection. In this study we explore the differences in viral shedding between carrier and non-carrier animals, quantify the transmission rate of FMDV infection from...

Journal: :modares journal of medical sciences: pathobiology 2008
azam bolhasani mohammad taghikhani nahid ghasemi hooriyeh soleimanjahi sima rafati

objective: dna vaccines have been widely used to develop immunity against various pathogens including parasites and viruses. the potential of dna vaccine to induce an effective immune response is related to the expression levels of the encoded protein in eukaryotic cells. therefore, optimization of plasmid dna delivery system is a major concern in protein expression in order to make an efficien...

Journal: Nanomedicine Journal 2015
Hamideh Parhiz Maryam Hashemi Mohammad Ramezani

Gene therapy as a modern therapeutic approach has not yet advanced to a globally-approved therapeutic approach. Lack of adequate reliable gene delivery system seems to be one of the major reasons from the pharmaceutical biotechnology point of view. Main obstacles delaying successful application of human gene therapy are presented in this review. The unique advantages of non-biological gene carr...

Background and Aims: Currently, there are antiviral chemicals used to treat viral infections accompanied by limitations such as high levels of toxicity and adverse effects in humans, the emergence of drug-resistant viral strains, low numbers, and limited diversity. Therefore, it is necessary to evaluate new photochemical to obtain new therapeutic methods. The present study was conducted to eval...

Journal: :journal of paramedical sciences 0
afshin khavari department of hepatitis and aids, pasteur institute of iran, tehran, iran zahra orafa department of hepatitis and aids, pasteur institute of iran, tehran, iran mehrdad hashemi department of genetics, islamic azad university, tehran medical sciences branch,tehran,iran noorieh habibzadeh department of hepatitis and aids, pasteur institute of iran, tehran, iran azam bolhassani department of hepatitis and aids, pasteur institute of iran, tehran, iran

delivery of exogenous materials such as nucleic acids, peptides, proteins, and drugs into cells is an important strategy in modern cellular and molecular biology. recently, the development of gene carriers for efficient gene transfer into cells has attracted a great attention. furthermore, lack of effective drug delivery is one of the major problems of cancer chemotherapy. many physical methods...

2014
Mayumi Toda Yasuna Kobayashi Tomotake Koizumi Koji Saito Masayuki Ohbayashi Noriko Kohyama Takeshi Aoki Masahiko Murakami Hajime Yasuhara Toshinori Yamamoto

Human organic solute carrier protein 1 (hOSCP1) is a Na(+)-independent multispecific organic solute transporter. To date, several studies have revealed that gene mutations of the transporters are likely to be associated with some diseases; however, there are no data concerning the genetic polymorphism of the hOSCP1 gene in Japanese patients with non-viral liver carcinoma (LC). In the present st...

Journal: :iranian journal of basic medical sciences 0
faezeh moghadam ariaee pharmaceutical research center, school of pharmacy, mashhad university of medical sciences, mashhad, iran maryam hashemi nanotechnology research center, school of pharmacy, mashhad university of medical sciences, mashhad, iran sara amel farzad pharmaceutical research center, school of pharmacy, mashhad university of medical sciences, mashhad, iran khalil abnous pharmaceutical research center, school of pharmacy, mashhad university of medical sciences, mashhad, iran mohammad ramezani nanotechnology research center, school of pharmacy, mashhad university of medical sciences, mashhad, iran

objective(s): first, 10-bromodecanoic acid was covalently attached to all available surface primary amines of ppi g2 and g3 to increase their lipophilicity. in the subsequent step, ppis were conjugated to the alkylcarboxylate groups of alkylcarboxylate-ppi derivatives to increase the number of surface primary amines. physicochemical properties of modified ppis were determined. transfection expe...

Journal: :hepatitis monthly 0
paul carrier service d’hépato-gastroentérologie, chu limoges, 87042 limoges cédex, france; inserm, u850, f-87000 limoges, univ limoges, france; service d’hépato-gastroentérologie, chu limoges, 87042 limoges cédex, france. tel: +33-555056687, fax: +33-555056767 marilyne debette-gratien service d’hépato-gastroentérologie, chu limoges, 87042 limoges cédex, france; inserm, u850, f-87000 limoges, univ limoges, france murielle girard unité d’investigation clinique, centre hospitalier spécialisé esquirol, 87042 limoges, france jérémie jacques service d’hépato-gastroentérologie, chu limoges, 87042 limoges cédex, france philippe nubukpo pôle d’addictologie, centre hospitalier spécialisé esquirol, 87042 limoges, france véronique loustaud-ratti service d’hépato-gastroentérologie, chu limoges, 87042 limoges cédex, france; inserm, u850, f-87000 limoges, univ limoges, france

patients with psychiatric disorders are usually more exposed to multiple somatic illnesses, including liver diseases. specific links are established between psychiatric disorders and alcohol hepatitis, hepatitis b, and hepatitis c in the population as a whole, and specifically in drug abusers. metabolic syndrome criteria, and associated steatosis or non-alcoholic steato-hepatitis (nash) are fre...

2015
Jem Ma Ahn Dong Hyun Sinn Geum-Youn Gwak Yong-Han Paik Moon Seok Choi Joon Hyeok Lee Kwang Cheol Koh Seung Woon Paik Chun-Jen Liu

OBJECTIVES We investigated whether long-term clinical outcomes such as disease progression or inactive hepatitis B virus (HBV) carrier state can be predicted by baseline factors in hepatitis B e antigen (HBeAg)-negative HBV infected patients with an elevated viral load. METHODS A retrospective cohort of 527 HBeAg-negative chronic HBV infected patients with an elevated viral load (HBV DNA ≥ 2,...

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