In contrast to UCP1, the primary function of UCP3 is not the dissipation of energy. Rather, several lines of evidence suggest that UCP3 is related to cellular long-chain fatty acid homeostasis. If long-chain fatty acids enter the mitochondrial matrix in their non-esterified form, they cannot be metabolized and may exert deleterious effects. To test the feasibility that UCP3 exports fatty acid a...

1. The mechanism whereby p-chlorophenoxyisobutyrate (CPIB) lowers plasma non-esterified fatty acid concentrations has been studied in dogs by measuring the associated changes in adipose tissue metabolism. 2. CPIB lowered arterial concentrations of non-esterified fatty acids during isoprenaline infusion by a mean value of 41%. 3. This was accompanied by a proportionate decrease (45%) in the rele...

The occurrence of a negative energy balance (NEB) and concurrent metabolic changes may be responsible for impaired reproductive performance. A characteristic metabolic feature of NEB is the mobilization of body fat, reflected in an increased plasma non-esterified fatty acids (NEFA) concentration. High plasma concentration of NEFA is reflected in elevated NEFA follicular concentrations. The aim ...

The composition of plasma non-esterified fatty acids was investigated during glucose tolerance tests to determine changes in individual fatty acid concentrations after glucose administration and to determine whether differences existed between the individual fatty acid concentrations of maturity-onset diabetic and non-diabetic men. The mean fasting total nonesterified fatty acid concentration o...

Triacylglycerols have the potential to supply significant fatty acids for ATP production by the myocardium, yet at present the exact contribution of triglyceridederived fatty acid to the energy economy of the myocardium is unresolved. Chylomicrons and very-low-density lipoproteins both add to energy production but the degree of provision may be related to particle size of individual lipoprotein...

abstract         background and objective: the relationship between diabetes mellitus and increased risk of cardiovascular diseases has been demonstrated. the aim of this study was to determine the fatty acid profile of epicardial adipose tissue in diabetic and non-diabetic patients with cardiovascular disease.          methods: in this study, 28 diabetic and 40 nondiabetic patients were evalua...

Abbreviations: EC – embryogenic calli; EFA – esterified fatty acids; FA – fatty acids; FAME – fatty acid methyl ester; FFA – free fatty acid; GC – gas chromatography; GC-MS – gas chromatography and mass spectrometry; HS – hypocotyl segments; HSC – hypocotyl segments with incipient calli formation; LCFA – long-chain fatty acid; MCFA – mediumchain fatty acids; NEC – non-embryogenic calli; PCA – p...

The objective of this study was to investigate the mobilization of individual fatty acids from human subcutaneous adipose tissue in vivo. Concentrations of individual non-esterified fatty acids were measured in arterialized plasma and in the venous drainage from subcutaneous abdominal adipose tissue in eight normal subjects, after an overnight fast, and for the subsequent 6 h. Whilst the veno-a...