Nichel and Welch (9, 10), Broquisl et al. (1), Hill and Scott (6), and Welch et al. (16) found that ascorbic acid, a reducing agent, enhanced the for mation of citrovorum factor (CF) from folie acid (PGA). Nichel and Welch (9, 10), indicated that glucoascorbate augments the enzymic conversion of PGA to CF by liver tissue in vitro, while Welch et al. (16), administering glucoascorbate parenteral...

Electrochemical sensors and biosensors based on inhibition are sensitive methods to determine the concentration of toxic substances in environment and clinic applications. Heavy metal cations bind to biological molecules and inactive important enzyme systems, such as acetylcholinesterase (AChE). In this paper, the amperometric sensors and biosensors based on AChE inhibition were developed using...

ABSTRACT Anilines react with 5-nitroindoles in the presence of t-BuOK in N,N-dimethylformamide (DMF) to form 5-nitroso-4-arylaminoindoles that in turn when treated with N,O-bis(trimethylsilyl)acetamide cyclize to pyrrolo[3,2-a]phenazines. In an alternative approach pyrrolo[3,2-a]phenazines are formed from aminoindoles and nitroarenes. GRAPHICAL ABSTRACT