We report here a biophysical and biochemical approach to determine the differences in interactions of NiCR and NiCR-2H with DNA. Our goal is to determine whether such interactions are responsible for the recently observed differences in their cytotoxicity toward MCF-7 cancer cells. Viscosity measurement and fluorescence displacement titration indicated that both NiCR and NiCR-2H bind weakly to ...

In this study, commercial-grade NiCr (80 wt % Ni, 20 wt % Cr) and NiCrSi (55 wt % Ni, 40 wt % Cr, 5 wt % Si) were used as targets and the sputtering method was used to deposit NiCr and NiCrSi thin films on Al₂O₃ and Si substrates at room temperature under different deposition time. X-ray diffraction patterns showed that the NiCr and NiCrSi thin films were amorphous phase, and the field-effect s...

NiCr₂O₄ as a potential protection for thermal barrier coatings (TBCs) against the attack of molten calcium-magnesium-alumino-silicate (CMAS) was studied by a CMAS-contacting experiment. Atmospheric plasma sprayed coatings and sintered bulk materials were fabricated, covered with CMAS deposits, and exposed to 1200 °C for 24 h. Nano-sized CMAS-NiCr₂O₄ mixed powder was manufactured by ball milling...

BACKGROUND It has been suggested that inaccuracies in cancer registries are distorting UK survival statistics. This study compared the Northern Ireland Cancer Registry (NICR) database of living patients, with independent data held by Northern Ireland's General Practitioners (GPs) to compare and validate the recorded diagnoses and dates held by the registry. METHODS All 387 GP practice manager...

Mobilization of intracellular Ca(2+) stores regulates a multitude of cellular functions, but the role of intracellular Ca(2+) release via the ryanodine receptor (RyR) in the brain remains incompletely understood. We found that nitric oxide (NO) directly activates RyRs, which induce Ca(2+) release from intracellular stores of central neurons, and thereby promote prolonged Ca(2+) signalling in th...

The interconnected porosity of the Cr3C2–NiCr coatings obtained by high-velocity oxy fuel spraying is detrimental in corrosion and wear resistance applications. Laser treatments allow sealing of their surfaces through melting and resolidification of a thin superficial layer. A Nd:YAG laser beam was used to irradiate Cr3C2–NiCr coatings either in the continuous wave mode or at different repetiti...

Nitric oxide (NO) is a typical gaseous messenger involved in a wide range of biological processes. In our classical knowledge, effects of NO are largely achieved by activation of soluble guanylyl cyclase to form cyclic guanosine-3', 5'-monophosphate. However, emerging evidences have suggested another signaling mechanism mediated by NO: "S-nitrosylation" of target proteins. S-nitrosylation is a ...

The aim of the study was to compare the connective tissue response of Lewis rats to Ti, NiCr and AgPd alloys. It was found that implants were covered by collagen-rich, well vascularized capsules. Titanium was covered by the thinnest capsule (57 ± 20 μm) and AgPd alloy was covered by the thickest capsule (239 ± 50 μm). The PCNA+ cell prevalence in the capsules was lower for titanium than for AgP...

This study presents experimental and computational analyses of the phase composition mechanical behavior a functionally graded material (FGM) grading from 100 vol% 304L stainless steel (SS304L) to Ni-20Cr (NiCr) in 10 increments. The FGM was evaluated by extracting tensile specimens SS304L-rich NiCr-rich regions FGM, with former behaving ductile manner latter being relatively brittle. brittle r...

The aim of the present work is to evaluate activation energy (Ea) at different cathodic overpotentials (η) by potentiodynamic tests which were carried out temperatures Ni-based, NiCr-m, and NiCr-p porous electrodes, during alkaline electrolysis processes. On other hand, electrochemical stability electrodes was evaluated cyclic voltammetry after 1000 cycles operation potentiostatic 10 h −1.5 V v...