objective(s) lipocalin 2 (lcn2) is a 25-kda glycoprotein that has initially been extracted from neutrophil granules. expression of lcn2 is induced under various pathophysiological conditions. it is also known as an early marker of kidney and heart injury. high-level expression of recombinant lcn2 neutrophil gelatinase-associated(ngal) in insect cells was the aim of this study. materials and met...

background: hypertension is one the most common causes of chronic kidney disease (ckd). one of the major concerns in hypertensive patients is early detection of renal disorders. in the past, serum creatinine (scr) concentration was used as a marker of kidney function, but it proffers a late reflection of reduced glomerular filtration rate. cystatin c and neutrophil gelatinase-associated lipocal...

conclusions sepsis enhances the production of plasma ngal in critically ill neonates. thus plasma ngal can help clinicians diagnose sepsis in critically ill neonates during early phases. results the ngal levels were significantly higher in septic neonates compared with non-septic neonates (102.9 ± 69.9 ng/ml versus 29.2 ± 13.3 ng/ml, p value = 0.0001). an optimal cut off-point of 48 ng/ml for s...

Neutrophil gelatinase-associated lipocalin is currently one of the most interesting and enigmatic proteins involved in the development of malignancies. In this study, we found that the expression of neutrophil gelatinase-associated lipocalin was up-regulated in endometrial cancer tissues and cell lines, significantly increased in early-grade ones, suggesting it may serve as a biomarker for earl...

Background: Delayed graft function is a main complication after deceased donor kidney transplantation that adversely affects graft outcome. Difficulties in prediction and early detection of delayed graft function have hindered the ability to perform proper therapeutic interventions. We investigated whether measuring urinary interleukin 18 and neutrophi...

background early predictive biomarkers for acute kidney injury (aki) such as neutrophil elatinase-associated lipocalin (ngal) could identify patients who may benefit from early initiation of treatment. objectives we aimed to obtain a cut off point for aki prediction by urine ngal in kidney transplantation. patients and methods in a prospective cohort study, 64 adult who underwent kidney transpl...

background: delayed graft function is a main complication after deceased donor kidney transplantation that adversely affects graft outcome. difficulties in prediction and early detection of delayed graft function have hindered the ability to perform proper therapeutic interventions. we investigated whether measuring urinary interleukin 18 and neutrophil gelatinase-associated lipocalin as marker...

To observe the changes of neutrophil gelatinase associated apolipoprotein (neutrophil lipocalin), lipoprotein phospholipase A2 and inflammatory cytokine hypersensitive C-reactive protein in patients with coronary heart disease to explore correlation between serum lipoproteinassociated A2, lipocalin, degree artery disease. 200 inpatients cardiovascular department our hospital were divided into g...

background: two questions about diagnostic value of urinary neutrophil gelatin associated lipocalin (ungal) in detection of acute kidney injury (aki) in children have remained unanswered; first, which cut-off point of ungal has the highest value in detection of aki; and second when is the best time for measuring this biomarker in a patient? accordingly, the present study aimed to conduct a syst...

OBJECTIVES Sepsis is a life-threatening condition that arises when the response of the body to infection injures its own tissues and organs. The early prediction of sepsis by current clinical and laboratory methods remains inadequate. Serum neutrophil gelatinase-associated lipocalin level is increased in sepsis irrespective of renal dysfunction. Therefore, we aimed to correlate the serum neutro...