np-c is a severe, progressive and irreversible neurovisceral disease, which is invariably fatal. np-c is a rare disease, with an estimated minimal incidence of 1/120,000 live births . np-c is caused by mutations in npc1 (~95% of patients) or npc2 genes .defective npc1 and npc2 proteins result in a disruption of lipid metabolism . one of special features of this disorder is heterogeneous manifes...

the short and long term effects of chromium toxicity on brain catecholamines and acetylcholinesterase levels were investigated. rats were injected daily with varying amounts of chromium. the short term (2 h) administration of chromium (8 mmol/kg) reduced catecholamines level of cerebellum, mid-brain and brain-cortex by 22.8, 19.4 and 21.2% respectively. acetylcholinesterase activity was also re...

clinical neurology has been traditionally considered as an academic speciality in which the specialist regurgitates his/her knowledge of neurology without being able to do much for the patient. this attitude is no longer acceptable. surge of information and discoveries in neurosciences within the last two decades translated into therapeutic interventions which is literally life saving in some o...

how to cite this article: ashrafi mr, tavasoli ar. how we can put forward the diagnosis of npc disease: suspicion index. iran j child neu rol. 2015 autumn;9:4(suppl.1): 2-4. pls see pdf.

abstract aim: to assess anti-neuronal antibodies (na) prevalence and their correlation with neurological disorders and bowel habits in celiac disease (cd) patients. background: neurological manifestations are estimated to occur in about 10% of celiac disease patients and na to central nervous system (cns) and enteric nervous system (ens) are found in a significant proportion of them. little is ...

this paper reviews the current literature examining the pervasive symptom of fatigue experienced in three of the most common degenerative neurological conditions: multiple sclerosis (ms), parkinson’s disease (pd) and post-polio syndrome (pps). the existing literature can be considered under four headings definition and prevalence, type, cause, impact of fatigue. fatigue is a common symptom in d...

coenurosis is a disease of the central nervous system in sheep, caused by coenurus cerebralis , the larval stage of multiceps multiceps , which inhabits the small intestine of canidae. a case of regurgitations in a 2.5 month old lamb with acute coenurosis is being reported. the lamb was presented with a sudden onset of ataxia and re-gurgitations for 10 days. the post-mortem examination revealed...

Glial cells form a network in the central nervous system to support neurons and interact with them. The glia consist essentially of astrocytes that help with the nutrition of neurons and react in some cases of injury, oligodendrocytes that produce myelin, and microglia that are derived from the haemopoietic system and are concerned with the immunological defense of the nervous system. Experimen...

celiac disease or gluten sensitivity may initially present as one or more neurological signs and/or symptoms. on the other hand, it may be associated with or complicated by neurological manifestations. neurological presentations are rare in children but as many as 36% of adult patients present with neurological changes. with severe malnutrition after progression of celiac disease, different vit...

The short and long term effects of chromium toxicity on brain catecholamines and acetylcholinesterase levels were investigated. Rats were injected daily with varying amounts of chromium. The short term (2 h) administration of chromium (8 mmol/kg) reduced catecholamines level of cerebellum, mid-brain and brain-cortex by 22.8, 19.4 and 21.2% respectively. Acetylcholinesterase activity was also re...