neuroleptic malignant syndrome (nms) is a rare fatal medical complication that occurs as a result of dopaminergic receptor blockage in the caudate at the termination of the nigrostriatal pathways (1), and may occur at any time following consumption of dopamine antagonists. this disorder also occurs in cases of sudden discontinuation of dopamine agonists and antagonists (2,3). some studies have ...

neuroleptic malignant syndrome (nms) is a rare but life-threatening idiosyncratic side effect resulting from neuroleptic drugs. nms mainly occurs in patients treated with high-potency typical antipsychotics, but rarely caused by atypical antipsychotics. although nms is less common with atypical antipsychotic, but it seems that its incidence is rising due to increased administration of such drug...

Neuroleptic malignant syndrome (NMS) is a rare but life-threatening idiosyncratic side effect resulting from neuroleptic drugs. NMS mainly occurs in patients treated with high-potency typical antipsychotics, but rarely caused by atypical antipsychotics. Although NMS is less common with atypical antipsychotic, but it seems that its incidence is rising due to increased administration of such drug...

neuroleptic malignant syndrome (nms) is unusual but could be a lethal reaction associated with neuroleptic drugs. it occurs in almost 0.07-2.2% of patients under treatment with neuroleptics. there are some medical treatments that may also be helpful for its treatment, including dopamine agonists, muscle relaxants, and electroconvulsive therapy (ect). we present this case to alert the clinicians...

Neuroleptic malignant syndrome is an uncommon but dangerous complication of antipsychotic drugs, characterized by clinical symptoms that include hyperthermia, severe muscle rigidity, autonomic dysfunction, and altered mental state. Serum creatine kinase (CK) elevation occurs in over 90% of cases. Many diagnostic criteria sets for neuroleptic malignant syndrome have been proposed, all of which i...

OBJECTIVE The pathophysiology of neuroleptic malignant syndrome is mainly explained by a central hypodopaminergic state. The familial occurrence of neuroleptic malignant syndrome suggests the involvement of a genetic mechanism in the predisposition to the syndrome. Therefore, the authors examined the association between the TaqI A polymorphism of the dopamine D(2) receptor gene (DRD(2)), which ...

this paper reports five cases of neuroleptic malignant syndrome, admitted to shahid navab safavi psychiatric center during a period of six months. the onset and course of syndrome, types of drugs prescribed, and the variety of symptoms, were studied. results showed that early diagnosis of the syndrome, cessation of neuroleptic drugs, and classical treatment were efective in saving the lives of ...

BACKGROUND: The neuroleptic malignant syndrome is a rare but serious condition mainly associated with antipsychotic medication. There are controversies as to whether "classical" forms of neuroleptic malignant syndrome can occur in patients given atypical antipsychotics. The serotonin syndrome is caused by drug-induced excess of intrasynaptic 5-hydroxytryptamine. The possible relationship betwee...