the effect of odonthobuthos doriae (o.d) scorpion venom at 0/3, 1 and 3, 10 µg/ml concentrations were investigated on nerve-muscle transmission, using the twitch tension technique. a concentration of 0.3 µg/ml caused a small change in the twitch height in response to indirect muscle stimulation, but higher concentrations (1, 3, 10 µg/ml) caused a transient augmentation in twitch response follow...

Normally, skeletal muscles contract when receiving impulses from the nerve centres along the motor nerve fibres and the neuro-muscular junction. Acetylcholine is considered to be the chemical mediator involved in these functions. The neuro-muscular junction appears to be highly susceptible to the influence of chemicals of divergent nature and other biological substances present in the body. Whi...

In a patient with myasthenic syndrome neuro-muscular transmission was characterised by depression and facilitation. The relative extent of these two processes varied between muscles, and in the one muscle with time. Guanidine HCl treatment corrected the electrophysiological defect. Oral choline increased muscle action potential amplitude in response to single shocks. Intravenous choline produce...