objective(s):theneuroprotective effect of lithium has been attributed to its therapeutic action. however, the role of glial cells particularly astrocytes, and the possible interactions between neurons and astrocytes in neuroprotective effects of lithium have been disregarded. thus, the aim of this study was to evaluate the direct effects of lithium on brain derived neurotrophic factor (bdnf) an...

Objective(s):Theneuroprotective effect of lithium has been attributed to its therapeutic action. However, the role of glial cells particularly astrocytes, and the possible interactions between neurons and astrocytes in neuroprotective effects of lithium have been disregarded. Thus, the aim of this study was to evaluate the direct effects of lithium on brain derived neurotrophic factor (BDNF) an...

s – poster presentations (selected; first author) Jaken RJ, Marcus MA, Joosten EA, Deumens R. Spatio-temporal rewiring of the spinal nociceptivenetwork in a rat model of neuropathic pain.(2010) NeuPSIG 3 International Congress on Neuropathic Pain, Athens (GR) Jaken RJ, Knaepen L, van der Meulen I, Marcus M, Joosten E, Deumens R. Chronic neuropathicpain: structural changes in the sup...

The new science called Sentiomics aims to identify the dynamic patterns that endow living systems with capacity feel and become conscious. One of most promising fields investigation in is development ‘education’ human brain organoids sentient useful for promotion health (also new) field Regenerative Neuromedicine. Here, we discuss type informational-rich input necessary make a organoid experime...

Conscious perceptual processing involves the sequential activation of cortical networks at several brain locations, and the onset of oscillatory synchrony affecting the same neuronal population. How do the earlier activated circuits sustain their excitation to synchronize with the later ones? We call such a sustaining process "meta-potentiation", and propose that it depends on neuroastroglial i...

Studies on the cellular and molecular mechanism of neurotransmitter receptor-signaling and of neuronal and glial cell responses to stresses seem to be important to elucidate the action mechanism of centrally-acting drugs and to develop novel therapeutics against several diseases in the brain. The present review shows our findings with regard to the membrane receptor-signaling mechanism includin...

Metabolism is involved directly or indirectly in all processes conducted in living cells. The brain, popularly viewed as a neuronal-glial complex, gets most of its energy from the oxygen-dependent metabolism of glucose, and the mitochondrial pyruvate dehydrogenase complex (PDC) plays a key regulatory role during the oxidation of glucose. Pyruvate dehydrogenase kinase (also called PDC kinase or ...

Disturbed brain water homeostasis with swelling of astroglial cells is a common complication in stroke, trauma, and meningitis and is considered to be a major cause of permanent brain damage. Astroglial cells possess the water channel aquaporin 4 (AQP4). Recent studies from our laboratory have shown that glutamate, acting on group I metabotropic glutamate receptors (mGluRs), increases the perme...

The neuron-astrocyte synaptic complex is a fundamental operational unit of the nervous system. Astroglia regulate synaptic glutamate, via neurotransmitter transport by GLT1/EAAT2. Astroglial mechanisms underlying this essential neuron-glial communication are not known. We now show that presynaptic terminals regulate astroglial synaptic functions, GLT1/EAAT2, via kappa B-motif binding phosphopro...