BACKGROUND The kidney is tasked with a number of metabolic functions in the body. In its role as a detoxifier and primary eliminator of xenobiotics, it becomes vulnerable to developing injuries. Currently, over 1 million people in the world are living on renal replacement therapies (RRTs). The case in sub-Sahara African countries like Nigeria and South Africa is not any better than the global t...

Medicinal plants may serve as a vital source of potentially useful new compounds for the development of effective therapy to combat a variety of kidney problems. Many herbs have been prove to be effectual as nephroprotective agents while many more are claimed to be nephroprotective but there is lack of any such scientific evidence to support such claims. Developing a satisfactory herbal therapy...

The present study was undertaken to evaluate nephroprotective activity of different extracts of whole plant of Biophytum sensitivum in Wistar albino rats. Randomly selected animals were divided into five groups of six animals each. The test extracts were administered orally at a dose of 200 mg/kg. Gentamicin was administered at a dose of 40 mg/kg i.p. to the rats for 7 days. On eighth day all t...

Medicinal plants may serve as a vital source of potentially useful new compounds for the development of effective therapy to combat a variety of kidney problems. Many herbs have been proven to be effectual as nephroprotective agents while many more are claimed to be nephroprotective but there is lack of any such scientific evidence to support such claims. Developing a satisfactory herbal therap...

Orthosiphon stamineus is the one of the important medicinal plant which used for kidney based problems traditionally. In the present investigation the ethanolic extracts of O. stamineus leaves have been used for the nephroprotective activity. The ethylene glycol used to inducing the urolithiasis in albino rats. The rats are divided into four groups namely I (Normal), II (Ethylene glycol induced...

Medicinal plants may serve as a vital source of potentially useful new compounds for the development of effective therapy to combat a variety of kidney problems. Many herbs have been proven to be effectual as nephroprotective agents while many more are claimed to be nephroprotective but there is lack of any such scientific evidence to support such claims. Developing a satisfactory herbal therap...

Background & Aim: Mammea africana sabine (Guttiferae) stembark commonly used traditionally to treat various diseases and ailments was evaluated for nephroprotective activity against paracetamol – induced kidney injury in rats to confirm its use in the treatment of kidney diseases. Experimental:  The nephroprotective effect of the extract was evaluated by the determination of some kidn...

Background & Aim: Mammea africana sabine (Guttiferae) stembark commonly used traditionally to treat various diseases and ailments was evaluated for nephroprotective activity against paracetamol – induced kidney injury in rats to confirm its use in the treatment of kidney diseases. Experimental:  The nephroprotective effect of the extract was evaluated by the determination of some kidn...

background & aim: mammea africana sabine (guttiferae) stembark commonly used traditionally to treat various diseases and ailments was evaluated for nephroprotective activity against paracetamol – induced kidney injury in rats to confirm its use in the treatment of kidney diseases. experimental:  the nephroprotective effect of the extract was evaluated by the determination of some kidney fun...

objective(s): because of the high total phenolic contents of feijoa sellowiana , its nephroprotective effect was determined in 3,4-methylene dioxymethamphetamine (mdma) treated mice.   materials and methods: animals received 10, 20 and 40 mg/kg doses of aqueous or methanol extract of f. sellowiana leaves, intra-peritoneally. after one hour, an acute administration of mdma (20 mg/kg, ip) was inj...