Introduction: We describe a nephron-based dosimetry model for renal toxicity for radiopharmaceutical therapy suited to the nonuniform activity distribution of radiopharmaceutical. In radiopharmaceutical therapy, renal toxicity is observed while whole-kidney and renal cortex absorbed dose values are below toxicity thresholds established by external beam and targeted radiope ptid...

Developing a whole kidney model is important for effective diagnostic procedures and treating diseases. The modeling of multi-nephron network aids in developing the model. key aspect any nephron understanding pressure dynamics. governing equations dynamics depend on number nephrons their interactions. There are mathematical models to analyze local global behaviors single coupled nephrons. It di...

<span>Numerical analysis plays a vital role in the computational modeling of nephron. The solutions from numerical methods exhibit regular, period doubling, and irregular oscillations as global behavior. A single nephron compliance tubular model with transport mechanism autoregulatory has been developed using cellular automata framework this paper. Global emergent behavior biological syst...

12 Bonventre JV: Maladaptive proximal tubule repair: cell cycle arrest. Nephron Clin Pract 2014;127:61–64. 13 Portilla D: Apoptosis, fibrosis and senescence. Nephron Clin Pract 2014;127:65–69. 14 Andringa KK, Agarwal A: Role of hypoxia-inducible factors in acute kidney injury. Nephron Clin Pract 2014;127:70–74. 15 Fleig SV, Humphreys BD: Rationale of mesenchymal stem cell therapy in kidney inju...

The final nephron number in an adult kidney is regulated by nephron progenitor cell availability and collecting duct branching in the fetal period. Fetal environmental perturbations that cause reductions in cell numbers in these two compartments result in low nephron endowment. Previous work has shown that maternal dietary factors influence nephron progenitor cell availability, with both calori...

Experimental data for tubular pressure oscillations in rat kidneys are analyzed in order to examine the different types of synchronization that can arise between neighboring functional units. For rats with normal blood pressure, the individual unit (the nephron) typically exhibits regular oscillations in its tubular pressure and flow variations. For such rats, both in-phase and antiphase synchr...

Given the common pathways for uptake and synthesis for dopamine and serotonin, enhanced renal dopamine synthesis in response to increased substrate 3,4-dihydroxyphenylalanine (l-DOPA) is postulated to decrease renal serotonin synthesis. The present study compared the effects of chronic oral administration ofl-DOPA on dopamine and serotonin excretion in vivo, with the effects of enhanced dopamin...