introduction: early diagnosis and appropriate treatment is required in esophageal cancer due to its invasive nature. the aim of this study was to evaluate early post-esophagectomy complications in patients with esophageal cancer who received neoadjuvant chemoradiotherapy (nacr).   materials and methods: this randomized clinical trial was carried out between 2009 and 2011. patients with lower-th...

purpose : to evaluate the effectiveness of chemoreduction (crd) for globe saving in patients with intraocular retinoblastoma methods : in this interventional case series all patients with intraocular retinoblastoma were included and classified according to the international classification of retinoblastoma (icrb) from group a to e. six cycles of intravenous vincristine, etoposide and carboplati...

introduction: breast cancer is the most common cancer and the second cause of death in women. it is essential to have the highest level of confidence in axillary staging assessment. many surgeons and pathologists believe that fewer lymph nodes are present in axillary dissection specimens of women treated by neoadjuvant chemotherapy. consequently, the purpose of this study was to compare the lym...

Background: The rate of recurrence and mortality in high-risk prostate cancer remains high. On the other hand, the use of chemotherapy in metastatic prostate cancer has improved overall survival of patients. The aim of this study was to evaluate the effect of neoadjuvant chemotherapy alone on increasing survival of patients with high risk localized prostate cancer Methods: This is a systematic...

objectives: multidrug resistance (mdr), which may be due to the over expression of p-glycoprotein (pgp) and/or mrp, is a major problem in neoadjuvant chemotherapy of osteosarcoma. the aim of this study was to investigate the role of tc-99m mibi scan for predicting the response to pre-operative chemotherapy. materials and methods: twenty-five patients (12 males and 13 females, aged between 8 and...

esophageal cancer is one of the most common malignancies with a growing occurrence . it presently ranks ninth among the most frequent cancers in the world and the sixth leading cause of death from cancer . for a variety of reasons, the mainstream of patients with esophageal cancer is actually not suitable for esophagectomy. more than 50% have locally advanced unresectable or metastatic tumors a...

PURPOSE Recent studies have shown promising results of neoadjuvant therapy in prostate cancer (PC). The aim of this study was to evaluate the potential of [11C]Choline PET/CT in therapy response monitoring after combined neoadjuvant docetaxel chemotherapy and complete androgen blockade in locally advanced and high risk PC patients. RESULTS In [11C]Choline PET/CT there was a significant decrea...

CONTEXT Pancreatic cancer is still associated with a high mortality and morbidity for affected patients. To this date the role of neoadjuvant therapy in the standard treatment of pancreatic cancer remains elusive. The aim of our study was to review the latest results and current approaches in neoadjuvant therapy of pancreatic cancer. METHODS We performed a literature review for neoadjuvant th...

BACKGROUND Interest in the use of preoperative systemic treatment in the management of breast cancer has increased because such neoadjuvant therapy appears to reduce the extent of local surgery required. We compared the clinical end points of patients with breast cancer treated preoperatively with systemic therapy (neoadjuvant therapy) and of those treated postoperatively with the same regimen ...

The past few decades have seen an increase in both the role and the complexity of neoadjuvant therapy for breast cancer. Neoadjuvant therapy was initially described as systemic chemotherapy for inflammatory or locally advanced breast cancer but now entails a combination of chemotherapy, endocrine therapy, and targeted therapy. Neoadjuvant systemic therapy is employed for inoperable inflammatory...