Background: Necrotizing enterocolitis (NEC) is a lethal disease affecting newborns with significant morbidity and mortality rates. Moreover, it is the most eminent gastrointestinal threat affecting premature newborns. Unfortunately, early symptoms and signs are usually vague; therefore, there is a special demand for sensitive biomarkers in this regard. This study aimed to investigate the role o...

Purpose: The purpose of this study was to examine the usefulness of abdominal sonography in the diagnosis of necrotizing enterocolitis (NEC). Methods: We reviewed the medical records of 51 neonates who were diagnosed with NEC in the neonatal intensive care unit at Yeouido St. Mary’s Hospital of the Catholic University in Korea between January 2008 and December 2012. The neonates under­ went abd...

Background: Necrotizing enterocolitis (NEC) is a disease with high mortality. It is more present in premature infants and can also happen in term and late preterm neonates. It may affect any segment of the small intestine or colon. However, most commonly influences the terminal ileum and proximal ascending colon. This disease might damage the entire bowel, which can be...

Necrotizing enterocolitis (NEC) is a devastating intestinal disease of premature infants. Epidermal growth factor (EGF) is one of the most promising candidates in NEC prophylaxis. Autophagy regulates cell homeostasis, but uncontrolled activation of autophagy may lead to cellular injury. The aim was to evaluate the effects of EGF on intestinal autophagy in epithelial cells and in the rat NEC mod...

BACKGROUND Eosinophils infiltrate intestinal tissue during necrotizing enterocolitis (NEC) and adult bowel diseases. We theorized that epithelial damage causes eosinophilic activation and recruitment at NEC onset. OBJECTIVE We studied the relationship between persistent blood eosinophilia and medical or surgical complications during NEC. METHODS NEC cases and controls at MU Children's Hospi...

NEC is inflammatory necrosis of intestine with most common site being terminal ileum and ascending colon in preterm babies (1). The condition is typically seen in premature infants, and the timing of its onset is generally inversely proportional to the gestational age of the baby at birth, i.e. The earlier a baby is born, longer is the time of risk for NEC in premature babies. The incidence of ...

Abdominal aortic aneurysm (AAA) is a common aortic disease with a progressive nature. There is no approved pharmacological treatment to effectively slow aneurysm growth or prevent rupture. Necroptosis is a form of programmed necrosis that is regulated by receptor-interacting protein kinases (RIPs). We have recently demonstrated that the lack of RIP3 in mice prevented aneurysm formation. The goa...

background: necrotizing enterocolitis (nec) is one of the most destructive diseases associated with conditions of neonatal prematurity. supplementation with enteral prebiotics may reduce the incidence of nec, especially in infants who fed exclusively with breast-milk. therefore, we compared the efficacy and safety of enteral supplementation of a prebiotic mixture (short chain galacto-oligosacch...

nec is inflammatory necrosis of intestine with most common site being terminal ileum and ascending colon in preterm babies (1). the condition is typically seen in premature infants, and the timing of its onset is generally inversely proportional to the gestational age of the baby at birth, i.e. the earlier a baby is born, longer is the time of risk for nec in premature babies. the incidence of ...