the aim of me present work was to investigate rhe potential utility of nanoparticles made of chitosan (cs) and also cs chemically modified with polyethylene glycol (cs-peg) as new vehicles for improving na^al vaccine delivery. for mis purpose, diphtheria toxoid (dt) was chosen as a model antigen. dt was entrapped within nanoparticles made of cs of different molecular weight, and also made of cs...

Thallium-201/Nasal administration/Biological safety/Preclinical study. Nasal administration of thallium-201 (Tl) has previously been shown to be useful for the assessment of olfactory nerve connectivity in vivo. We assessed the biological effects of nasal Tl administration in mice to determine its safety before conducting clinical trials on humans. Tl uptake was evaluated in normal mice (n = 5)...

OBJECTIVE 1) To estimate the effectiveness of intranasal administration of CpG DNA alone on allergic rhinitis compared with intradermal administration; and 2) to find out how CpG DNA therapy is useful in treatment of allergic rhinitis. STUDY DESIGN Mice were intraperitoneally sensitized and intranasally challenged with Japanese cedar. Therapy with CpG DNA alone was also performed during chall...

OBJECTIVE The study objective was to investigate the prophylactic efficacy of montelukast (MLK) 10 mg in suppressing seasonal allergic rhinitis (SAR) symptoms induced by Japanese cedar (JC) pollen and to determine how many days before exposure to JC in the artificial exposure chamber (OHIO chamber) would be optimal to start administration. METHODS This was a single-institution, double-blind, ...

Currently, Nasal drug delivery has been recognized as a very promising route for delivery of therapeutic compounds including biopharmaceuticals 1 . Nasal administration is a logical choice for topical nasal treatments such as antihistamines and corticosteroids. The nasal mucosa has also received attention as a viable means of systemic administration of analgesics, sedatives, hormones, cardiovas...

Dahlin, M. 2000. Nasal Administration of Compounds Active in the Central Nervous System. Exploring the Olfactory Pathway. Acta Universitatits Uppsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy 240. 48 pp. Uppsala. ISBN 91-554-4872-0. The nasal administration of drugs offers advantages over administration by intravenous injection. Drugs can be rapidly abs...