The binary adsolubilization behaviors of 2-naphthol +biphenyl and 2-naphthol +1, 3-dichlorobenzene in a cationic fluorocarbon surfactant adsorbed layer formed on TiO2 have been investigated as a function of pH. In the binary adsolubilization of 2-naphthol+biphenyl, the adsolubilized amount of 2-naphthol increases gradually until pH 7 and then sharply with a further increase of pH, whereas the a...

Fluorescence probes based on excited state proton transfer (ESPT) have been recently developed for microheterogeneous media. The ESPT behaviour of a series of substituted naphthols (4-chl oro-1-naphthol, 5-amino-1-naphthol , 4-methoxy1-naphthol, 7-methoxy-2-naphthol , 3-amino-2-naphthol, 6-bromo-2naphthol and 1-bromo-2-naphthol) is investigated in liposomes, using steady state and time resolved...

Hyaluronan is a biopolymer suitable as a targeting unit in drug delivery systems according to affinity of hyaluronan to CD-44 receptor of cancer cells. We suppose that hyaluronan, when interacts with cationic surfactant, influences hydration of Stern layer of CTAB which affects fluorescence properties of 1-naphthol. We study excited state proton transfer of 1-naphthol in aqueous solution and in...

The mechanism(s) of toxicity of 1-naphthol and two of its possible metabolites, 1,2- and 1,4-naphthoquinone, to freshly isolated rat hepatocytes has been studied. 1-Naphthol and both naphthoquinones exhibited a dose-dependent toxicity to hepatocytes. [1-14C]-1-Naphthol was metabolised by hepatocytes predominantly to its glucuronic acid and sulphate ester conjugates, but small amounts of covalen...

The effect of some unsubstituted aromatic amines and their oand p-hydroxylated derivatives on isolated rat-liver mito chondria has been studied. The o-hydroxylated amines inhibited oxygen uptake in the presence of nicotinamide adenine dinucleotide-dependent respiratory substrates. Of the other compounds only l-amino-4-naphthol inhibited oxygen uptake. The Buccinate oxidase system was inhibited ...

Pseudomonas sp. strain C4 metabolizes carbaryl (1-naphthyl-N-methylcarbamate) as the sole source of carbon and energy via 1-naphthol, 1,2-dihydroxynaphthalene, and gentisate. 1-Naphthol-2-hydroxylase (1-NH) was purified 9.1-fold to homogeneity from Pseudomonas sp. strain C4. Gel filtration and sodium dodecyl sulfate-polyacrylamide gel electrophoresis showed that the enzyme is a homodimer with a...

The reaction of dimethyl acetylenedicarboxylate with OH-acid such as 2-naphthol in the presence of trimethyl or triphenyl phosphite under solvent-free conditions produce oxaphosphaphenanthrene derivatives in good yields. Also, the reaction of dimethyl acetylenedicarboxylate and trimethyl phosphite in the presence of 1-naphthol leads to succinate derivatives in excellent yields. Using triethyl p...

Substrates that are specific for certain UDP-glucuronosyltransferase (UGT) isoforms are usually used as specific inhibitors to identify UGT isoforms responsible for the glucuronidation of drugs. 1-Naphthol and 4-nitrophenol are probe substrates for human UGT1A6. In the present study, we found that UGT1A1-catalyzed estradiol 3-O-glucuronide formation and UGT1A4-catalyzed imipramine N-glucuronide...

The polycyclic aromatic hydrocarbon naphthalene is an environmental pollutant, a component of jet fuel and, since 2000, has been reclassified as a potential human carcinogen. Few studies of the in vitro human metabolism of naphthalene are available and these focus primarily on lung metabolism. The current studies were performed to characterize naphthalene metabolism by human cytochromes P450 (C...

OBJECTIVES Malondialdehyde (MDA), a lipid peroxidation by-product, has been widely used as an indicator of oxidative stress. Urinary 2-naphthol, a urinary PAH metabolite, is used as a marker of ambient particulate exposure and is associated with lung cancer and chronic obstructive pulmonary disease. However, the stability and intra-individual variation associated with urinary MDA and 2-naphthol...